Search

Displaying results 4161 - 4170 of 10000 in total
  1. Drug

    Cantuzumab mertansine

    go.drugbank.com/drugs/DB17239
    Experimental

    Synonyms: oxopropyl)maytansine (1:4), -oxopropyl)maytansine (1:4)
  2. Drug

    Povidone

    go.drugbank.com/drugs/DB11061
    ApprovedInvestigationalWithdrawn

    Povidone, also known as polyvinylpyrrolidone (PVP) or polyvidone, is a synthetic water-soluble polymer made from the monomer N-vinylpyrrolidone used as a binder in many pharmaceutical tablets and lubricant … When in complex with iodine, [DB06812] displays antiseptic properties where the iodine, a bactericidal component, mainly contributes to this effect, and povidone acts as a carrier [A32988].

    Synonyms: 1-vinyl-2-pyrrolidinone polymer, 1-ethenyl-2-pyrrolidinone homopolymerMixtures: FULLFRESH 5,60 MG/2,40 MG TEK DOZLUK GÖZ DAMLASI, ÇÖZELTİ, Murine Tears 1
  3. Drug

    Magrolimab

    go.drugbank.com/drugs/DB16225
    Investigational

    Magrolimab is under investigation in clinical trial NCT02953782 (Trial of Magrolimab (Hu5f9-g4) in Combination With Cetuximab in Participants With Solid Tumors and Advanced Colorectal Cancer).

    Synonyms: Immunoglobulin g4(225-proline), anti-(human cd47 antigen) (human-mus musculus monoclonal hu5f9-g4 .gamma.4-chain), disulfide with human-mus musculus monoclonal hu5f9-g4 .kappa.-chain, dimer, )) (8.8.10) (1-117)-homo sapiens ighg4*01 (ch1 (118-2
  4. Drug

    Sabatolimab

    go.drugbank.com/drugs/DB16322
    Investigational

    Sabatolimab is under investigation in clinical trial NCT03946670 (A Study of MBG453 in Combination With Hypomethylating Agents in Subjects With IPSS-R Intermediate, High or Very High Risk Myelodysplastic

    Synonyms: Immunoglobulin g4 (226-proline,de-c-terminal-lysine), anti-(human hepatitis virus a cellular receptor 2) (human-mus musculus monoclonal clone nvs260714 .gamma.4-chain), disulfide with human-mus musculus, Immunoglobulin g4-kappa, anti-(homo sapiens havcr2 (hepatitis a virus cellular receptor 2, t-cell immunoglobulin mucin family member 3, tim-3, tim3, timd3, cd366)), humanized monoclonal antibody
  5. Target

    4-trimethylaminobutyraldehyde dehydrogenase

    go.drugbank.com/bio_entities/BE0000287
    TargetHumans

    Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with ...

    Polypeptides: 4-trimethylaminobutyraldehyde dehydrogenaseFunction: 4-trimethylammoniobutyraldehyde dehydrogenase activity
  6. Target

    Dipeptidyl peptidase 4

    go.drugbank.com/bio_entities/BE0000854
    TargetEnzymeHumans

    Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed:10900005, PubMed:10951221, PubMed:11772392, PubMed:17287217). Acts as a positive regulator of ...

    Polypeptides: Dipeptidyl peptidase 4
  7. Target

    Platelet factor 4

    go.drugbank.com/bio_entities/BE0001129
    TargetHumans

    Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule.

    Polypeptides: Platelet factor 4Synonyms: PF-4, C-X-C motif chemokine 4
  8. Target

    Sphingomyelin phosphodiesterase 4

    go.drugbank.com/bio_entities/BE0002300
    TargetHumans

    Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:16517606, PubMed:25180167). It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, an...

    Polypeptides: Sphingomyelin phosphodiesterase 4
  9. Target

    Histone deacetylase 4

    go.drugbank.com/bio_entities/BE0003523
    TargetHumans

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation...

    Polypeptides: Histone deacetylase 4
  10. Target

    4-hydroxyphenylpyruvate dioxygenase

    go.drugbank.com/bio_entities/BE0004267
    TargetStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)

    Polypeptides: 4-hydroxyphenylpyruvate dioxygenaseFunction: 4-hydroxyphenylpyruvate dioxygenase activity