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Diphenhydramine
go.drugbank.com/drugs/DB01075ApprovedInvestigationalAs a result, diphenhydramine is being investigated for its anxiolytic and anti-depressant properties. … Diphenhydramine has also been shown to be implicated in a number of neurotransmitter systems that affect behaviour including dopamine, norepinephrine, serotonin, acetylcholine, and opioid [A1539].
Synonyms: N-(2-(diphenylmethoxy)ethyl)-N,N-dimethylamine, 2-(benzhydryloxy)-N,N-dimethylethylamineInternational brands: Dormarex 2Hepatitis B immune globulin
go.drugbank.com/drugs/DB05276ApprovedInvestigationalInfection with hepatitis B may lead to hepatocellular carcinoma, a type of liver cancer. Therefore, the hepatitis-B vaccines are cancer-preventing vaccines. … Long-term hepatitis B immune globulin (HBIG) has been shown to reduce hepatitis B virus (HBV) reinfection in patients transplanted for hepatitis B.
Synonyms: Hepatitis B immune globulin, Hepatitis B immune globulin humanCategories: hepatitis B immunoglobulinCabergoline
go.drugbank.com/drugs/DB00248ApprovedInvestigationalCabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. … Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Categories: Heterocyclic Compounds with 4 or More Rings, P-glycoprotein substrates with a Narrow Therapeutic IndexSynonyms: (8R)-6-allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide, (8β)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamideTheophylline
go.drugbank.com/drugs/DB00277ApprovedInvestigationalMechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. … A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities.
Mixtures: TUSBRON-A JARABE, Theophylline 0.8mg/ml In 5% Dextrose InjCategories: Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic IndexIron sucrose
go.drugbank.com/drugs/DB09146ApprovedInvestigationalIron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis … Due to less side effects than iron dextran, iron sucrose is more preferred in chronic kidney disease patients.
Mixtures: Marnatal FInternational brands: Ferosoft SDocusate
go.drugbank.com/drugs/DB11089ApprovedInvestigationalAdditionally, it does not appear to lessen symptoms associated with constipation such as abdominal cramps. Still docusate is available in over-the-counter products as a common laxative. … Docusate, or dioctyl sulfosuccinate, is a stool softener indicated for the treatment of constipation[A32201].
Mixtures: Sennosides 8.6 Mg and Docusate Sodium 50 Mg Tablets, Senna Plus Standardized Senna Concentrate 8.6 mg and Docusate Sodium 50 mg EachProducts: H E B Stool Softener laxative, Lax-A SoftMethylphenidate
go.drugbank.com/drugs/DB00422ApprovedInvestigational[A177550] Clinical findings have shown that children with ADHD have an abnormality in the dopamine transporter gene (DAT1), the D4 receptor gene (DRD-4), and/or the D2 receptor gene that may be at least … Long-acting formulations of psychostimulants such as methylphenidate, [DB01576], and [DB01255] are considered the most effective and widely used treatment for ADHD, and are considered first-line options
Mixtures: MEDIKINET MR, MEDIKINET MRCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 3-RingDNA gyrase subunit A
go.drugbank.com/bio_entities/BE0000366TargetHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.
Polypeptides: DNA gyrase subunit AAcetyl-coenzyme A synthetase
go.drugbank.com/bio_entities/BE0001916TargetSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.
Polypeptides: Acetyl-coenzyme A synthetaseNucleoside diphosphate kinase A
go.drugbank.com/bio_entities/BE0003106TargetEnzymeHumansMay also function as a Mg(2+)-dependent 3'-5' DNA exonuclease, excising nucleotides from 3' single-stranded DNA or DNA with 3' single strand overhangs, suggesting a role in DNA nucleolytic processing ( … May function as a Mg(2+)-dependent single-stranded DNA endonuclease as part of the SET complex, cooperating with the 3'-5' exonuclease TREX1 to mediate apoptotic DNA fragmentation in cytotoxic T lymphocytes
Polypeptides: Nucleoside diphosphate kinase ASynonyms: NDPK A, NDP kinase A