DNA gyrase subunit A

BE0000366ProteinHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)gyrA

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. It is acted on by 19 drugs in DrugBank.

Gene name
gyrA
UniProtKB entry
P43700Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
880 residues · 97,817 Da
Also known as
5.6.2.2 · 5.99.1.3

Resolves to

Protein
UniProtP43700UniProt nameGYRA_HAEIN
Gene
NCBI Gene950199GenBank1574722
Pharmacology
KEGGhin:HI1264
Drugs

What you can answer from here — as of September 07, 2019

19DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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57+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA gyrase subunit A, how selective are they, and which programs against it are still in active trials?

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