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Displaying results 4281 - 4290 of 10000 in total
  1. Drug

    Aspartame

    go.drugbank.com/drugs/DB00168
    InvestigationalNutraceutical

    Flavoring agent sweeter than sugar, metabolized as phenylalanine and aspartic acid.

  2. Drug

    Fidaxomicin

    go.drugbank.com/drugs/DB08874
    ApprovedInvestigational

    [A190492] The antibacterial activity of fidaxomicin is distinct from macrolides and rifamycins, as the bactericidal activity is time-dependent, and not concentration-dependent. … [A190501] Because fidaxomicin contains an 18-membered lactone ring in its structure, it is referred to as a macrocyclic lactone antibiotic drug.

  3. Drug

    Sulfatolamide

    go.drugbank.com/drugs/DB13547
    Experimental

    Categories: Genito Urinary System and Sex Hormones
  4. Drug

    Piflufolastat F 18

    go.drugbank.com/drugs/DB14805
    ApprovedInvestigational

    Prostate cancer is the most common non-cutaneous malignancy affecting men in North America[A235344] - despite this, an ongoing challenge in prostate cancer therapy is the difficulty in imaging the extent … Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein expressed in many tissues that plays a role in folate uptake and neurotransmitter release - it is expressed in the prostate at

  5. Drug

    Poractant alfa

    go.drugbank.com/drugs/DB09113
    ApprovedInvestigational

    Poractant alfa is a pulmonary surfactant marketed as Curosurf in the United States and Canada. … It is used to treat Respiratory Distress Syndrome (RDS) in premature infants with an endogenous pulmonary surfactant deficiency.

    Categories: Complex Mixtures
  6. Target

    Cyclin-dependent kinase 9

    go.drugbank.com/bio_entities/BE0002207
    TargetHumans

    Also catalyzes phosphorylation of histone H1.4 (H1-4) at 'Ser-187' (H1.4S187Ph), a modification associated with transcription activation (PubMed:28539972). … This complex is inactive when in the 7SK snRNP complex form (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed

    Synonyms: Tat-associated kinase complex catalytic subunit
  7. Target

    Proteasome subunit beta type-5

    go.drugbank.com/bio_entities/BE0002348
    TargetHumans

    Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity … Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.

    Synonyms: Multicatalytic endopeptidase complex epsilon chain
  8. Drug

    Damoctocog alfa pegol

    go.drugbank.com/drugs/DB14700
    ApprovedInvestigational

    [A38907] Also known as, BAY94-9027, Damoctocog alfa pegol is a longer-acting Factor VIII therapy formulated with polyethylene glycol (PEG) to reduce the number of infusions necessary to prevent bleeds … In recent years, various extended half-life factor VIII and factor IX preparations have been studied and gained approval.

  9. Drug

    EVT 302

    go.drugbank.com/drugs/DB06057
    Investigational

    EVT 302 is an orally active, potent, highly selective and reversible inhibitor of MAO-B. It is in the development for smoking cessation, and potential for disease modification in Alzheimer's disease.

  10. Drug

    Terfenadine

    go.drugbank.com/drugs/DB00342
    ApprovedWithdrawn

    In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation.

    Categories: Antihistamines for Systemic UseSynonyms: (RS)-1-(4-tert-butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}-butan-1-ol