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Displaying results 4341 - 4350 of 8700 in total
  1. Drug

    Genistein

    go.drugbank.com/drugs/DB01645
    Investigational

    An isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. … Further, genistein is a phytoestrogen which has selective estrogen receptor modulator properties.

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  2. Drug

    Rapacuronium

    go.drugbank.com/drugs/DB04834
    ApprovedWithdrawn

    Rapacuronium was withdrawn in 2001 in many countries due to risk of fatal bronchospasm.

  3. Pathway

    Alprenolol Action Pathway

    smpdb.ca/view/SMP0000297
    Drug action

    Alprenolol (also known as alfeprol, alpheprol or alprenololum) a beta blocker (non-selective) that block beta-1 adrenergic receptor in heart. … Blocking beta-1 adrenergic receptor could prevent the binding of epinephrine and norepinephrine, which could efficiently reduce blood pressure and heart rate.

    Drugs: ATP · Alprenolol · Potassium cation · Calcium
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2
  4. Pathway

    Betaxolol Action Pathway

    smpdb.ca/view/SMP0000299
    Drug action

    Betaxolol (also known as Betoptic or Lokren) is a selective beta blocker that can block beta1-adrenergic receptors and beta2-adrenergic receptors. Blocking of beta1-adrenergic receptors in heart and vascular smooth muscle can lead to red...

    Drugs: ATP · Betaxolol · Potassium cation · Calcium
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2
  5. Pathway

    Esmolol Action Pathway

    smpdb.ca/view/SMP0000301
    Drug action

    Esmolol, sold as Brevibloc, is a cardioselective beta-1 receptor blocker drug. … Esmolol is injected intravenously, and when it enters the heart, it binds to the beta-1 adrenergic receptor, preventing signalling.

    Drugs: ATP · Esmolol · Potassium cation · Calcium
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2
  6. Pathway

    Nadolol Action Pathway

    smpdb.ca/view/SMP0000303
    Drug action

    Nadolol (also known as Corgard or Solgol) is a beta blocker (non-selective) that are used for treat high blood pressure or chest pain. Nadolol bind to beta1-adrenergic receptors in heart and vascular smooth muscle to block the binding of...

    Drugs: ATP · Nadolol · Potassium cation · Calcium
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2
  7. Pathway

    Oxprenolol Action Pathway

    smpdb.ca/view/SMP0000304
    Drug action

    Oxprenolol (also known as Trasacor or Trasicor) is a beta blocker (non-selective) that are used for treat high blood pressure or chest pain. Oxprenolol bind to beta1-adrenergic receptors in heart and vascular smooth muscle to block the b...

    Drugs: ATP · Potassium cation · Calcium · Oxprenolol
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2
  8. Pathway

    Propranolol Action Pathway

    smpdb.ca/view/SMP0000307
    Drug action

    Propranolol, a non-cardioselective beta blocker, inhibits sympathetic stimulation by competing with neurotransmitters like catecholamines to bind beta(1)-adrenergic receptors of the heart and vascular smooth muscle. Propranolol binding r...

    Drugs: ATP · Propranolol · Potassium cation · Calcium
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2
  9. Pathway

    Quinidine Action Pathway

    smpdb.ca/view/SMP0000323
    Drug action

    Quinidine may be used to maintain sinus rhythm in atrial fibrillation or flutter and prevent recurrence of ventricular fibrillation or tachycardia.

    Drugs: ATP · Quinidine · Potassium cation · Calcium
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2
  10. Pathway

    Disopyramide Action Pathway

    smpdb.ca/view/SMP0000325
    Drug action

    Disopyramide may depress cardiac contractility, which could precipitate heart failure or Torsades de Pointes. … Disopyramide may be used to maintain rhythm in atrial fibrillation or flutter or to prevent recurrence of ventricular tachycardia or fibrillation.

    Drugs: ATP · Disopyramide · Potassium cation · Calcium
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2