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Displaying results 4351 - 4360 of 10000 in total
  1. Drug

    DOTA-Arg-Pro-Lys-Pro-Gln-Gln-Phe-2Thi-Gly-Leu-Met(O2)-NH2 Actinium AC-225

    go.drugbank.com/drugs/DB18208
    Experimental

    Synonyms: -2-amino-4-(methylsulfonyl)-, (2S)-, [225Ac]Butanamide, N2-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-3-(2-thienyl)-L-alanylglycyl-L-leucyl
  2. Target

    4-aminobutyrate aminotransferase GabT

    go.drugbank.com/bio_entities/BE0001510
    TargetEscherichia coli (strain K12)

    Thereby functions in a GABA degradation pathway that allows some E.coli strains to utilize GABA as a nitrogen source for growth (PubMed:12446648). … Also catalyzes the conversion of 5-aminovalerate to glutarate semialdehyde, as part of a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate (PubMed:30498244).

    Polypeptides: 4-aminobutyrate aminotransferase GabTFunction: 4-aminobutyrate transaminase activity
  3. Target

    UDP-glucose 4-epimerase

    go.drugbank.com/bio_entities/BE0001521
    TargetEnzymeHumans

    The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate.

    Polypeptides: UDP-glucose 4-epimeraseSynonyms: UDP-GalNAc 4-epimerase, UDP-GlcNAc 4-epimerase
  4. Target

    4-hydroxy-tetrahydrodipicolinate reductase

    go.drugbank.com/bio_entities/BE0001983
    TargetMycobacterium tuberculosis

    Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Can use both NADH and NADPH as a reductant, with NADH being 6-fold as effective as NADPH.

    Polypeptides: 4-hydroxy-tetrahydrodipicolinate reductaseFunction: 4-hydroxy-tetrahydrodipicolinate reductase
  5. Target

    Cyclin-dependent kinase 4

    go.drugbank.com/bio_entities/BE0002216
    TargetHumans

    Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity.

    Polypeptides: Cyclin-dependent kinase 4Synonyms: Cell division protein kinase 4
  6. Target

    Toll-like receptor 4

    go.drugbank.com/bio_entities/BE0002442
    TargetHumans

    Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream … Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production

    Polypeptides: Toll-like receptor 4
  7. Target

    4-hydroxybenzoyl-CoA thioesterase

    go.drugbank.com/bio_entities/BE0002496
    TargetPseudomonas sp. (strain CBS-3)

    Hydrolyzes 4-hydroxybenzoate-CoA, and to a lesser extent benzoyl-CoA and 4-chlorobenzoate-CoA. Not active against aliphatic acyl-CoA thioesters, including palmitoyl-CoA, hexanoyl-CoA and acetyl-CoA.

    Polypeptides: 4-hydroxybenzoyl-CoA thioesteraseFunction: 4-hydroxybenzoyl-CoA thioesterase activity
  8. Target

    4-hydroxybenzoyl-CoA thioesterase

    go.drugbank.com/bio_entities/BE0002575
    TargetArthrobacter sp.

    Polypeptides: 4-hydroxybenzoyl-CoA thioesteraseSynonyms: 4-HBA-CoA thioesterase
  9. Target

    Equilibrative nucleoside transporter 4

    go.drugbank.com/bio_entities/BE0004775
    TransporterTargetHumans

    Functions as a Na(+)- and Cl(-)-independent bidirectional transporter (PubMed:15448143, PubMed:16099839, PubMed:22396231, PubMed:31537831). … Utilizes the physiologic inside-negative membrane potential as a driving force to facilitate cellular uptake of organic cations (PubMed:15448143, PubMed:20592246, PubMed:22396231).

    Polypeptides: Equilibrative nucleoside transporter 4Synonyms: Solute carrier family 29 member 4
  10. Target

    Penicillin-binding protein 4

    go.drugbank.com/bio_entities/BE0008485
    TargetStaphylococcus aureus

    Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

    Polypeptides: Penicillin-binding protein 4