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Timolol Action Pathway
smpdb.ca/view/SMP0000659Drug actionAround the cell there are many transports happening through many different transporters, leading in and out of the cell Some of the transports into the cell include sodium and calcium, while transports … This enzyme is activated through the G-protein signalling cascade, which stems from the type-1 angiotensin II receptor.
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Dobutamine Action Pathway
smpdb.ca/view/SMP0000662Drug actionDobutamine can bind to beta-1 adrenergic receptor on the heart cell which lead to mild chronotropic, arrhythmogenic, hypertensive and vasodilative effects.
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Levobunolol Action Pathway
smpdb.ca/view/SMP0000666Drug actionLevobunolol (also known as Betagan) is an ophthalmic beta blocker (non-selective) that can produce cardiovascular effects and systemic pulmonary effects. Levobunolol bind to beta1-adrenergic and beta2-adrenergic receptors in heart and va...
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Metipranolol Action Pathway
smpdb.ca/view/SMP0000667Drug actionMetipranolol (also known as Betanol or Disorat) is an beta blocker (non-selective) that can used as an antihypertensive, antiarrhythmic and antiglaucoma agent. Metipranolol binds to beta1-adrenergic and beta2-adrenergic receptors in hear...
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Practolol Action Pathway
smpdb.ca/view/SMP0000669Drug actionPractolol (also known as Eraldin or Dalzic) is a beta blocker (non-selective) that are used for treat high blood pressure or chest pain. Practolol bind to beta1-adrenergic receptors in heart and vascular smooth muscle to block the bindin...
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126428Drug actionL-type calcium channels are the main current responsible for the late phase of the pacemaker potential. … It is proposed that this cation influx may also trigger the release of additional calcium ions from intracellular storage sites.
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Clidinium
go.drugbank.com/drugs/DB00771ApprovedIt is used for the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.
Categories: Drugs for Functional Gastrointestinal DisordersGenistein
go.drugbank.com/drugs/DB01645InvestigationalAn isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. … Further, genistein is a phytoestrogen which has selective estrogen receptor modulator properties.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesFlucloxacillin
go.drugbank.com/drugs/DB00301ApprovedInvestigationalWithdrawnAntibiotic analog of cloxacillin.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseProducts: Floxapen 2g Pulver zur Herstellung einer Injektions- bzw. Infusionslösung, Flucloxacillin WABO 1 g Pulver zur Herstellung einer Injektions-/InfusionslösungBenznidazole
go.drugbank.com/drugs/DB11989ApprovedInvestigational[L939] It is the first treatment made available in the United States for Chagas disease. … Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017.
Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates