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Displaying results 4371 - 4380 of 8700 in total
  1. Pathway

    Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126428
    Drug action

    L-type calcium channels are the main current responsible for the late phase of the pacemaker potential. … It is proposed that this cation influx may also trigger the release of additional calcium ions from intracellular storage sites.

    Drugs: Verapamil · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2
  2. Drug

    Mefloquine

    go.drugbank.com/drugs/DB00358
    Approved

    [L30623] Mefloquine, commonly known as Lariam, is an antimalarial drug used for the prevention and treatment of malaria caused by infection with Plasmodium vivax and Plasmodium falciparum. … Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world.

    Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
  3. Drug

    IL-2 pDNA

    go.drugbank.com/drugs/DB05935
    Experimental

    Vical incorporated has initiated a human Phase 1 study of an investigational method of delivering interleukin-2 (IL-2), a potent immune system stimulant, for patients with recurrent metastatic melanoma

  4. Drug

    NNZ-2591

    go.drugbank.com/drugs/DB15601
    Investigational

    [L11106] It is currently under development by Neuren Pharmaceuticals for the symptomatic treatment of Angelman, Phelan-McDermid, and Pitt Hopkins Syndromes. … NNZ-2591 (cyclo-L-glycyl-L-2-allylproline)[A189390] is an investigational synthetic analog of cyclic glycine-proline (cGP), a breakdown product of human insulin-like growth factor 1 (IGF-1), that has been

  5. Drug

    Acemetacin

    go.drugbank.com/drugs/DB13783
    ApprovedInvestigational

    Merck and Company in Germany as an attempt to provide a safer drug but other than the amelioration on the gastrointestinal effects, the metabolism of acetamicin led to the formation of indomethacin and

  6. Drug

    Coral snake (micrurus fulvius) immune globulin antivenin (equine)

    go.drugbank.com/drugs/DB13883
    Approved

    North American Coral Snake Antivenin (Equine) is a horse-derived antivenin indicated for the treatment of envenomation caused by North American coral snake bites.

  7. Drug

    Flucloxacillin

    go.drugbank.com/drugs/DB00301
    ApprovedInvestigationalWithdrawn

    Antibiotic analog of cloxacillin.

    Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseProducts: Floxapen 2g Pulver zur Herstellung einer Injektions- bzw. Infusionslösung, Flucloxacillin WABO 1 g Pulver zur Herstellung einer Injektions-/Infusionslösung
  8. Drug

    Difluprednate

    go.drugbank.com/drugs/DB06781
    ApprovedInvestigational

    It is indicated for treatment of endogenous anterior uveiti. … Difluprednate is a topical corticosteroid indicated for the treatment of infammation and pain associated with ocular surgery. It is a butyrate ester of 6(α), 9(α)-difluoro prednisolone acetate.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  9. Drug

    Telcagepant

    go.drugbank.com/drugs/DB12228
    Investigational

    It is an antagonist of the receptor for calcitonin gene-related peptide (CGRP), a primary neuropeptide involved in the pathophysiology of migraine. … Telcagepant has been investigated for the treatment of Migraine.

  10. Pathway

    Atenolol Action Pathway

    smpdb.ca/view/SMP0000298
    Drug action

    Atenolol, trade name Tenormin, is a beta blocker prescribed to treat hypertension. Atenolol is a selective beta-1-adrenoceptor antagonist targeting the heart and vascular smooth muscle to inhibit sympathetic activity. Binding of atenolol...

    Drugs: ATP · Atenolol · Potassium cation · Calcium
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2