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Displaying results 431 - 440 of 10000 in total
  1. Drug

    Ezetimibe

    go.drugbank.com/drugs/DB00973
    ApprovedInvestigational

    C1-Like 1 (NPC1L1), and is unique in that it does not affect the absorption of fat-soluble nutrients such as fat-soluble vitamins, triglycerides, or bile acids. … [A33313] In genetically NPC1L1-deficient mice, a 70% reduction in intestinal cholesterol absorption was seen, and these mice were insensitive to ezetimibe treatment - it was determined based on these findings

    Mixtures: TIAZOMET ® A 40/10 TABLETAS, LIPIVAN E ® 10 MG / 10 MGCategories: Heterocyclic Compounds, 1-Ring, Hypolipidemic Agents Indicated for Hyperlipidemia
  2. Target

    Interleukin-10

    go.drugbank.com/bio_entities/BE0002484
    TargetHumans

    Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetram...

    Polypeptides: Interleukin-10Synonyms: IL-10
  3. Target

    Aquaporin-10

    go.drugbank.com/bio_entities/BE0018706
    TransporterHumans

    Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:11573934, PubMed:12084581, PubMed:217338...

    Polypeptides: Aquaporin-10Synonyms: AQP-10, Aquaglyceroporin-10
  4. Drug

    Pipotiazine

    go.drugbank.com/drugs/DB01621
    ApprovedInvestigationalWithdrawn

    Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. … However, it produces a high incidence of extra pyramidal reactions. It is used for the maintenance treatment of chronic non-agitated schizophrenic patients.

    Products: PIPORTIL ® L-4SOLUCION INYECTABLE AL 2.5% (100 MG)., TRIPIPOT® SOLUCIÓN INYECTABLE 25 MG/ML
  5. Drug

    Chlorpheniramine

    go.drugbank.com/drugs/DB01114
    ApprovedInvestigational

    A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications.

    Mixtures: Medicament Pour Le Rhume, Nuit, A-FERİN 300 MG/2 MG/10 MG KAPSÜL, 20 ADETCategories: Heterocyclic Compounds, 1-Ring, Antihistamines for Systemic Use
  6. Drug

    Tranexamic acid

    go.drugbank.com/drugs/DB00302
    ApprovedInvestigational

    It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent. … Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding.

    Synonyms: trans-4-aminomethylcyclohexane-1-carboxylic acidProducts: TRANSAMINE 100 MG/ML IV ENJ COZELTI, 10 ADET, Tranexamsäure Kabi 10 mg/ml Infusionslösung
  7. Drug

    Nitroglycerin

    go.drugbank.com/drugs/DB00727
    ApprovedInvestigational

    [A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina.[A249970] Nitroglycerin causes vasodilation in both arteries and veins. … Nitroglycerin, also known as glyceryl trinitrate,[A180169] is an organic nitrate and a vasodilating agent [L38369] that was first discovered in 1847.

    Mixtures: NITROGLICERINA 0.1 MG/ML EN DEXTROSA 5% SOLUCION INYECTABLE, .-400mcg/mlCategories: Compounds used in a research, industrial, or household setting, Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
  8. Drug

    Dyphylline

    go.drugbank.com/drugs/DB00651
    ApprovedWithdrawn

    Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis.

    Mixtures: ESPEKTAN A ŞURUP, 100 ML, ESPEKTAN ŞURUP, 100 MLCategories: Drugs for Obstructive Airway Diseases
  9. Drug

    Methylprednisolone

    go.drugbank.com/drugs/DB00959
    ApprovedInvestigationalVet approved

    [L10785] In the outbreak of COVID-19, low dose methylprednisolone-based therapy was successful in treating COVID-19-associated pneumonia in one patient with long-term immunosuppression. … Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone].[A188811] It was first described in the literature in the late 1950s.

    Mixtures: Physicians EZ Use M-pred, Physicians EZ Use M-predCategories: Experimental Unapproved Treatments for COVID-19, Compounds used in a research, industrial, or household setting
  10. Drug

    Sulfacetamide

    go.drugbank.com/drugs/DB00634
    Approved

    An anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections.

    Synonyms: N(1)-Acetylsulfanilamide, N(1)-Acetyl-4-aminophenylsulfonamideInternational brands: Blef-10