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Immunoglobulin heavy constant gamma 4
go.drugbank.com/bio_entities/BE0005089TargetHumansIg gamma-4 (IgG4) isotype does not elicit antibody-dependent cellular cytotoxicity (ADDC) or complement-dependent cytotoxicity (CDC).
Polypeptides: Immunoglobulin heavy constant gamma 4Synonyms: Ig gamma-4 chain C regionInward rectifier potassium channel 4
go.drugbank.com/bio_entities/BE0005187TargetHumansInward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as externa...
Polypeptides: Inward rectifier potassium channel 4Synonyms: Potassium channel, inwardly rectifying subfamily J member 4DNA topoisomerase 4 subunit A
go.drugbank.com/bio_entities/BE0008383TargetStaphylococcus aureusTopoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Polypeptides: DNA topoisomerase 4 subunit ACalcium-dependent protein kinase 4
go.drugbank.com/bio_entities/BE0009256TargetPlasmodium falciparum (isolate 3D7)Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (PubMed:19307175, PubMed:19666141). Plays a central role in the host erythrocyte...
Polypeptides: Calcium-dependent protein kinase 4Sphingosine 1-phosphate receptor 4
go.drugbank.com/bio_entities/BE0009882TargetHumansG protein-coupled receptor highly expressed in immune cells, where it regulates immune response and cytokine production. Functions as a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P). Upon S1P binding, promotes regulator...
Polypeptides: Sphingosine 1-phosphate receptor 4Synonyms: S1P receptor 4, S1P receptor Edg-6Zinc acetate
go.drugbank.com/drugs/DB14487ApprovedInvestigationalMixtures: Diphenhydramine D, CALPRAX CLEAR®Products: Senior B, Neat 3B Baby BProbable L-ascorbate-6-phosphate lactonase UlaG
go.drugbank.com/bio_entities/BE0004089TargetEscherichia coli (strain K12)Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions.
Polypeptides: Probable L-ascorbate-6-phosphate lactonase UlaGFunction: L-ascorbate 6-phosphate lactonase activityMitogen-activated protein kinase kinase kinase 6
go.drugbank.com/bio_entities/BE0009469TargetHumansComponent of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways
Polypeptides: Mitogen-activated protein kinase kinase kinase 6Tumor necrosis factor receptor superfamily member 6
go.drugbank.com/bio_entities/BE0010463TargetHumansThe secreted isoforms 2 to 6 block apoptosis (in vitro)
Polypeptides: Tumor necrosis factor receptor superfamily member 6Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
go.drugbank.com/bio_entities/BE0014062TargetHumansRate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) that catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine, thereby controlling the flux of glucose
Polypeptides: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1Synonyms: D-fructose-6-phosphate amidotransferase 1, Glutamine:fructose-6-phosphate amidotransferase 1