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Displaying results 4451 - 4460 of 10000 in total
  1. Target

    Tumor necrosis factor ligand superfamily member 11

    go.drugbank.com/bio_entities/BE0003517
    TargetHumans

    which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene

    Synonyms: Receptor activator of nuclear factor kappa-B ligand
  2. Target

    Hepatocyte nuclear factor 4-alpha

    go.drugbank.com/bio_entities/BE0004019
    TargetHumans

    Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922)...

    Synonyms: Nuclear receptor subfamily 2 group A member 1
  3. Drug

    Susoctocog alfa

    go.drugbank.com/drugs/DB11606
    ApprovedInvestigational

    Intravenous susoctocog alfa is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor VIII (FVIII) product that has recently been approved for the treatment of bleeding episodes in adults … Susoctocog alfa is a glycoprotein containing a 90 kDa heavy chain and a 80 kDa light chain with the naturally-occuring B domain replaced with a twenty-four amino acid linker.

    Synonyms: Porcine recombinant factor VIII B-domain truncated, Antihemophilic factor porcine, B-domain truncated recombinant
  4. Drug

    Tafasitamab

    go.drugbank.com/drugs/DB15044
    ApprovedInvestigational

    [L15302] It is produced using recombinant DNA technology in Chinese hamster ovary cells, and contains an IgG1/2 hybrid Fc-domain which has been modified with 2 amino acid substitutions to enhance its cytotoxicity … [L15292,A191829] The CD19 surface protein is highly expressed on the surface of B-cells, where it appears to play a role in enhancing B-cell receptor signaling.

    Categories: Lymphoma, B-Cell
  5. Drug

    Ginkgo biloba

    go.drugbank.com/drugs/DB01381
    ApprovedInvestigationalNutraceutical

    It is originally native to China, and _ginkgo biloba_ extract has been used in traditional Chinese medicine for centuries. … Lactones include ginkgolide A, ginkgolide B, ginkgolide C, bilobalide, and ginkgotoxin, a lactone that is structurally related to [pyridoxine].

    Mixtures: DOMINGO 5/5/80 MG EFERVESAN TABLET, 30 ADET, DOMINGO 5/5/80 MG EFERVESAN TABLET, 90 ADETCategories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Cytochrome P-450 CYP3A Inducers
  6. Drug

    Selumetinib

    go.drugbank.com/drugs/DB11689
    ApprovedInvestigational

    [A193608] It is a genetic, autosomal dominant condition resulting from mutations of the NF1 gene, which can lead to various complications, including the development of multiple tumours in the nervous system … NF-1 is considered rare, with an estimated incidence of 1/3000 individuals.

    Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  7. Drug

    Calcium

    go.drugbank.com/drugs/DB01373
    ApprovedInvestigationalNutraceutical

    Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. … Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium.

    Mixtures: GNC Mega Teen, Mag/cal 1:1 Capsules W Vitamin DCategories: ascorbic acid (vit C) and calcium
  8. Drug

    Methoxyamine

    go.drugbank.com/drugs/DB06328
    Investigational

  9. Target

    Glutamate carboxypeptidase 2

    go.drugbank.com/bio_entities/BE0000568
    TargetHumans

    Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory n...

    Synonyms: Cell growth-inhibiting gene 27 protein
  10. Target

    Homeodomain-interacting protein kinase 3

    go.drugbank.com/bio_entities/BE0009448
    TargetHumans

    Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. … Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2.

    Synonyms: Androgen receptor-interacting nuclear protein kinase