Glutamate carboxypeptidase 2

BE0000568ProteinHumansFOLH1

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. It is acted on by 26 drugs in DrugBank.

Gene name
FOLH1
UniProtKB entry
Q04609Swiss-Prot
Cellular location
Cell membrane
Residues / weight
750 residues · 84,330 Da
Also known as
3.4.17.21 · Cell growth-inhibiting gene 27 protein · FGCP · Folate hydrolase 1 · FOLH

Resolves to

Protein
UniProtQ04609UniProt nameFOLH1_HUMAN
Gene
HGNCHGNC:3788NCBI Gene2346GenBank190664GeneCardsFOLH1
Pharmacology
IUPHAR/GtoPdb1606KEGGhsa:2346
Structure
PDB1Z8LPDB2C6CPDB2C6G
Drugs

What you can answer from here — as of September 07, 2019

26DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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102+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamate carboxypeptidase 2, how selective are they, and which programs against it are still in active trials?

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