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Tumor necrosis factor ligand superfamily member 11
go.drugbank.com/bio_entities/BE0003517TargetHumanswhich is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene
Synonyms: Receptor activator of nuclear factor kappa-B ligandHepatocyte nuclear factor 4-alpha
go.drugbank.com/bio_entities/BE0004019TargetHumansTranscriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922)...
Synonyms: Nuclear receptor subfamily 2 group A member 1Glutamate carboxypeptidase 2
go.drugbank.com/bio_entities/BE0000568TargetHumansHas both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory n...
Synonyms: Cell growth-inhibiting gene 27 proteinHomeodomain-interacting protein kinase 3
go.drugbank.com/bio_entities/BE0009448TargetHumansEnhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. … Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2.
Synonyms: Androgen receptor-interacting nuclear protein kinaseNuvaxovid
go.drugbank.com/drugs/DB15810ApprovedInvestigational[A243789] Antibodies directed against the S protein are capable of blocking S-hACE2 interactions and neutralizing viral particles and are present in convalescent patients and those who have been inoculated … (Fractions A and C from _Quillaja saponaria_ extract).
Synonyms: SARS-CoV-2 rS, SARS-CoV-2 rS Nanoparticle VaccineH3B-8800
go.drugbank.com/drugs/DB14017InvestigationalH3B-8800 is a novel spliceosome inhibitor developed by H3 Biomedicine [L2551].
Categories: Heterocyclic Compounds, 1-RingSynonyms: (2S,3S,4E,6S,7R,10R)-7,10-Dihydroxy-3,7-dimethyl-12-oxo-2-[(2E,4E,6R)-6-(2-pyridinyl)-2,4-heptadien-2-yl]oxacyclododec-4-en-6-yl 4-methyl-1-piperazinecarboxylate, (2S,3S,4E,6S,7R,10R)-7,10-Dihydroxy-3,7-Dimethyl-12-Oxo-2-[(2E,4E,6R)-6-(Pyridin-2-Yl)Hepta-2,4-Dien-2-Yl]Oxacyclododec-4-En-6-Yl 4-Methylpiperazine-1-CarboxylateIvarmacitinib
go.drugbank.com/drugs/DB16756InvestigationalIvarmacitinib (SHR0302) is a selective inhibitor of Janus kinase 1 (JAK1) under investigation for the treatment of various immuno-inflammatory conditions.
Categories: Janus Kinase 1, antagonists & inhibitorsGalidesivir
go.drugbank.com/drugs/DB11676InvestigationalGalidesivir is an adenosine analogue that has been investigated for use against Zaire Ebolavirus. … [L12039,L12084] Phase 1 clinical trials have begun to determine the safety of this drug in humans.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: Immucillin A, Immucillin-ADeoxyribonuclease I
go.drugbank.com/drugs/DB16523Investigationalsymptoms requiring parenteral antibiotics, aerosolized human DNase I has been administered to patients with cystic fibrosis[A227723]. … Deoxyribonuclease I (DNase I) is a human enzyme responsible for the digestion of extracellular DNA7[A227723]. It is normally found in saliva, urine, pancreatic secretions, and blood[A227723].
Categories: Deoxyribonuclease I, antagonists & inhibitorsSynonyms: DNase I, Deoxyribonuclease INUC B1000
go.drugbank.com/drugs/DB05242Experimentalthe RNAi response against a targeted disease causing gene. … On January 11, 2008, it was announced that NUC B1000 was entering a phase 1 human safety study of its experimental treatment for chronic Hepatitis B virus (HBV) infection.