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Displaying results 4471 - 4480 of 10000 in total
  1. Target

    A-type voltage-gated potassium channel KCND1

    go.drugbank.com/bio_entities/BE0004726
    TargetHumans

    Exhibits a low-threshold A-type current with a hyperpolarized steady-state inactivation midpoint and the recovery process was steeply voltage-dependent, with recovery being markedly faster at more negative … Mediates A-type current I(SA) in suprachiasmatic nucleus (SCN) neurons.

    Polypeptides: A-type voltage-gated potassium channel KCND1Function: A-type (transient outward) potassium channel activity
  2. Target

    cAMP-dependent protein kinase (Protein kinase A)

    go.drugbank.com/bio_entities/BE0010127
    TargetHumans

    Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, histone H1.4 (H1-4), PSMC5/RPT6, PJA2, RYR2, RORA, SLC6A6, SOX9, UHRF1 and VASP (PubMed:15178447, PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334 … Phosphorylates a large number of substrates in the cytoplasm and the nucleus

  3. Drug

    Propranolol

    go.drugbank.com/drugs/DB00571
    ApprovedInvestigational

    Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors. … [L6904] Propranolol is used to treat a number of conditions but most commonly is used for hypertension.[L6901,L6904,L6907] Propranolol was granted FDA approval on 13 November 1967.[L6904]

    Mixtures: ARTENSOL® H 40 MG TABLETAS, Inderide-40 TabCategories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, P-glycoprotein inhibitors
  4. Drug

    Malathion

    go.drugbank.com/drugs/DB00772
    Approved

    Malathion is a parasympathomimetic organophosphate compound that is used as an insecticide for the treatment of head lice. … Malathion is an irreversible cholinesterase inhibitor and has low human toxicity.

    Categories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 SubstratesSynonyms: O,O-dimethyl S-(1,2-bis(ethoxycarbonyl)ethyl), O,O-dimethyl S-1,2-di(ethoxycarbamyl)ethyl
  5. Target

    V-type proton ATPase catalytic subunit A

    go.drugbank.com/bio_entities/BE0003569
    TargetHumans

    Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates … May play a role in neurite development and synaptic connectivity (PubMed:29668857)

    Polypeptides: V-type proton ATPase catalytic subunit ASynonyms: V-ATPase subunit A
  6. Target

    Nuclear receptor subfamily 4immunitygroup A member 1

    go.drugbank.com/bio_entities/BE0010494
    TargetHumans

    Plays a role in the vascular response to injury (By similarity)

    Polypeptides: Nuclear receptor subfamily 4immunitygroup A member 1
  7. Target

    Cationic amino acid transporter 4

    go.drugbank.com/bio_entities/BE0000052
    TargetHumans

    Involved in the transport of the cationic amino acids (arginine, lysine and ornithine)

    Polypeptides: Cationic amino acid transporter 4Synonyms: CAT-4, Solute carrier family 7 member 4
  8. Target

    Glutamate receptor ionotropic, kainate 4

    go.drugbank.com/bio_entities/BE0000827
    TargetHumans

    Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel. Cannot form functional channels on its own (PubMed:8263508).

    Polypeptides: Glutamate receptor ionotropic, kainate 4
  9. Target

    Carminomycin 4-O-methyltransferase DnrK

    go.drugbank.com/bio_entities/BE0001712
    TargetStreptomyces peucetius

    In vivo, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the 4-O-position of carminomycin to form daunorubicin. … In vitro, it also methylates the anthracyclines rhodomycin D (10-carbomethoxy-13-deoxycarminomycin) and 13-deoxy-carminomycin at the 4-hydroxyl position.

    Polypeptides: Carminomycin 4-O-methyltransferase DnrKSynonyms: Anthracycline 4-O-methyltransferase
  10. Target

    Excitatory amino acid transporter 4

    go.drugbank.com/bio_entities/BE0002270
    TargetHumans

    Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. … Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable)

    Polypeptides: Excitatory amino acid transporter 4