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Mesoridazine
go.drugbank.com/drugs/DB00933ApprovedWithdrawnA phenothiazine antipsychotic with effects similar to chlorpromazine.
Categories: Dopamine D2 Receptor Antagonists, Cytochrome P-450 SubstratesSynonyms: 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylsulfinyl phenothiazine, 10-(2(1-Methyl-2-piperidyl)ethyl)-2-(methylsulfinyl)phenothiazine3,3'-diindolylmethane
go.drugbank.com/drugs/DB11875InvestigationalDiindolylmethane has been used in trials studying the prevention and treatment of SLE, Prostate Cancer, Cervical Dysplasia, Stage I Prostate Cancer, and Stage II Prostate Cancer, among others.
Categories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 2-RingOrforglipron
go.drugbank.com/drugs/DB18964ApprovedInvestigational[L56123] On April 1, 2026, the US FDA granted approval to orforglipron for use alongside diet and exercise to aid in weight reduction in certain patient populations. … Orforglipron is a first-in-class oral, non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist.
Categories: GLP-1 Agonists, Cytochrome P-450 SubstratesSynonyms: -c]pyridin-5-yl]carbonyl]-5-[(4S)-tetrahydro-2,2-dim, 1,2,4-Oxadiazol-5(2H)-one, 3-[(1S,2S)-1-[2-[[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazol-1-yl]-2,4,6,7-tetrahydro-4-methyl-5H-pyrazolo[4,3Adrenoleukodystrophy, X-Linked
smpdb.ca/view/SMP0000516DiseaseSeizures are a typical symptom in many affected individuals in the the end stages of the disease progression. … Loss of vision is an early finding in some patients and is a prominent feature at some stage in most affected individuals.
Enzymes: Carnitine O-acetyltransferase, Peroxisomal carnitine O-octanoyltransferaseCarnitine-Acylcarnitine Translocase Deficiency
smpdb.ca/view/SMP0000517DiseaseIndividuals with CACT deficiency also usually have excess ammonia in the blood (hyperammonemia), an enlarged liver (hepatomegaly), and a weakened heart muscle (cardiomyopathy). … Others who are afflicted with a milder form of the disorder develop signs and symptoms in early childhood and are at risk for nervous system damage, liver failure, coma, and death.
Enzymes: Carnitine O-acetyltransferase, Peroxisomal carnitine O-octanoyltransferaseAdrenoleukodystrophy, X-Linked
smpdb.ca/view/SMP0125745DiseaseSeizures are a typical symptom in many affected individuals in the the end stages of the disease progression. … Loss of vision is an early finding in some patients and is a prominent feature at some stage in most affected individuals.
Enzymes: Carnitine O-acetyltransferase, Peroxisomal carnitine O-octanoyltransferaseRavulizumab
go.drugbank.com/drugs/DB11580ApprovedInvestigationalRavulizumab is a potent and selective complement 5 (C5) inhibitor. It is a humanized monoclonal IgG2/4 kappa antibody produced in Chinese hamster ovary (CHO) cells. … [A244465] Ravulizumab was first approved by the FDA on December 21, 2018, for the treatment of paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome in children and adults.
Products: ULTOMIRIS ®, Ultomiris 300 mg/3 mL İnfüzyonluk Çözelti Hazırlamak İçin Konsantre (1 adet)Vibegron
go.drugbank.com/drugs/DB14895ApprovedInvestigational[L28305] Vibegron was first approved in Japan in September 2018 for the treatment of overactive bladder,[A226050] a condition associated with distressing symptoms of urge urinary incontinence, urgency, … On December 23, 2020, vibegron was approved for the same indication in adults. It is available as oral tablets under the market name GEMTESA.
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesCarnitine-Acylcarnitine Translocase Deficiency
smpdb.ca/view/SMP0125746DiseaseIndividuals with CACT deficiency also usually have excess ammonia in the blood (hyperammonemia), an enlarged liver (hepatomegaly), and a weakened heart muscle (cardiomyopathy). … Others who are afflicted with a milder form of the disorder develop signs and symptoms in early childhood and are at risk for nervous system damage, liver failure, coma, and death.
Enzymes: Carnitine O-acetyltransferase, Peroxisomal carnitine O-octanoyltransferaseFesoterodine
go.drugbank.com/drugs/DB06702ApprovedFesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome.
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesProducts: TOVIAZ 4 MG, TOVIAZ 4 mg prolonged-release tablets