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Displaying results 451 - 460 of 10000 in total
  1. Drug

    Orlistat

    go.drugbank.com/drugs/DB01083
    ApprovedInvestigational

    It was approved by the FDA for use in combination with a reduced-calorie diet in 1999. … [L11130] This drug is a generally well-tolerated and effective weight-loss aid and is now available in both over-the-counter[L31963] and prescription preparations, depending on the dosage quantity.

    Products: ORLISTAT EG
  2. Drug

    Ostrea edulis shell

    go.drugbank.com/drugs/DB14251
    Investigational

    Ostrea edulis shell is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.

    Synonyms: European Flat Oyster Shell
  3. Drug

    Zopiclone

    go.drugbank.com/drugs/DB01198
    ApprovedInvestigational

    Zopiclone is a novel hypnotic agent used in the treatment of insomnia. Its mechanism of action is based on modulating benzodiazepine receptors. … In addition to zopiclone's benzodiazepine pharmacological properties it also has some barbiturate-like properties.

    Products: ZOPICLONE EG
  4. Pathway

    2-Ketoglutarate Dehydrogenase Complex Deficiency

    smpdb.ca/view/SMP0000549
    Disease

    oxoglutarate dehydrogenase complex (OGDC). … 2-Ketoglutarate dehydrogenase complex deficiency, also known as alpha-ketoglutarate dehydrogenase deficiency or oxoglutaric aciduria, is an autosomal recessive disorder of the Krebs cycle caused by a defective

    Drugs: Pyruvic acid · Biotin · Succinic acid · NADH · ATP · Magnesium cation +4 more
    Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
  5. Drug

    Bromazepam

    go.drugbank.com/drugs/DB01558
    ApprovedIllicit

    One of the benzodiazepines that is used in the treatment of anxiety disorders. It is a Schedule IV drug in the U.S. and Canada and under the Convention on Psychotropic Substances.

    Products: BROMAZEPAM EG, BROMAZEPAM N&P
  6. Drug

    Albuterol

    go.drugbank.com/drugs/DB01001
    ApprovedInvestigationalVet approved

    Salbutamol (Albuterol [USAN]) is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. … It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart.

    Mixtures: SALBUTAMOLO E IPRATROPIO BROMURO EG, Combivent nebuliser solution in unit dose vialProducts: VoSpire ER, Albuterol Sulfate ER
  7. Drug

    Ursodeoxycholic acid

    go.drugbank.com/drugs/DB01586
    ApprovedInvestigational

    [A256272] UDCA was first approved by the FDA in 1987 for dissolution of gallstones and for primary biliary cirrhosis in 1996. … [A256272,A256277] UDCA has been used to treat liver disease for decades: its first use in traditional medicine dates back more than a hundred years.

    Products: ACIDO URSODESOSSICOLICO EG, ACIDO URSODESOSSICOLICO EG STADA
  8. Drug

    Clonazepam

    go.drugbank.com/drugs/DB01068
    ApprovedIllicitInvestigational

    [FDA Label][A175438,A175441,L5572,F3763,F3787,F3796] Since being first patented in 1960 and then released for sale from Roche in the US in 1975,[T469,T472] clonazepam has experienced a storied history … in the treatment of the aforementioned medical conditions.

    Synonyms: 5-(2-chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one, 5-(2-chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-oneProducts: CLONAZEPAM EG
  9. Pathway

    Pyruvate Dehydrogenase Complex Deficiency

    smpdb.ca/view/SMP0000212
    Disease

    PDHA1 encodes the pyruvate dehydrogenase complex (PDC) a critical complex that converts pyruvate from glycolysis to acetyl CoA for the citric acid cycle. … Pyruvate dehydrogenase complex deficiency results from a mutation in the E1-alpha polypeptide gene (PDHA1).

    Drugs: Pyruvic acid · Biotin · Adenosine phosphate · Glutathione · NADH · ATP +13 more
    Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
  10. Pathway

    Mitochondrial Complex II Deficiency

    smpdb.ca/view/SMP0000548
    Disease

    Interestingly, complex II deficiency gene mutation carriers may be at an increased risk for certain cancers. … Because complex II is found in the mitochondria, CII deficiency is technically considered a mitochondrial disease.

    Drugs: Pyruvic acid · Biotin · Succinic acid · NADH · ATP · Magnesium cation +4 more
    Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial