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Displaying results 4591 - 4600 of 10000 in total
  1. Target

    Short transient receptor potential channel 4

    go.drugbank.com/bio_entities/BE0020751
    TargetHumans

    Forms a homomeric ion channel or a heteromeric ion channel with TRPC1; the heteromeric ion channel has reduced calcium permeability compared to the homomeric channel (PubMed:39478185). … Acts as a cell-cell contact-dependent endothelial calcium entry channel (PubMed:19996314).

    Polypeptides: Short transient receptor potential channel 4Synonyms: hTrp-4, Trp-related protein 4
  2. Indication

    Grade 1, grade 2, grade 3, grade 4 Urinary Tract Infection

    go.drugbank.com/conditions/DBCOND0128761
    Drugs: Amikacin · Cycloserine · Tetracycline
    Synonyms: Grade 4 Urinary Tract Infection, Grade 4 Urinary Tract Infections
  3. Target

    Neuronal acetylcholine receptor subunit alpha-4

    go.drugbank.com/bio_entities/BE0000849
    TargetHumans

    acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a

    Polypeptides: Neuronal acetylcholine receptor subunit alpha-4
  4. Target

    Cytochrome b6-f complex subunit 4

    go.drugbank.com/bio_entities/BE0002473
    TargetMastigocladus laminosus

    Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.

    Polypeptides: Cytochrome b6-f complex subunit 4
  5. Target

    Sodium channel regulatory subunit beta-4

    go.drugbank.com/bio_entities/BE0003638
    TargetHumans

    Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operat...

    Polypeptides: Sodium channel regulatory subunit beta-4
  6. Target

    Receptor tyrosine-protein kinase erbB-4

    go.drugbank.com/bio_entities/BE0004772
    TargetHumans

    Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A … Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1.

    Polypeptides: Receptor tyrosine-protein kinase erbB-4Synonyms: Proto-oncogene-like protein c-ErbB-4
  7. Target

    Phosphatidylinositol 4-kinase type 2-beta

    go.drugbank.com/bio_entities/BE0008985
    TargetHumans

    The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5

    Polypeptides: Phosphatidylinositol 4-kinase type 2-betaSynonyms: Phosphatidylinositol 4-kinase type II-beta
  8. Target

    Heat shock 70 kDa protein 4

    go.drugbank.com/bio_entities/BE0009027
    TargetHumans

    Polypeptides: Heat shock 70 kDa protein 4
  9. Target

    MAP/microtubule affinity-regulating kinase 4

    go.drugbank.com/bio_entities/BE0009482
    TargetHumans

    Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). … Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667).

    Polypeptides: MAP/microtubule affinity-regulating kinase 4
  10. Target

    Inositol polyphosphate 4-phosphatase type II

    go.drugbank.com/bio_entities/BE0011457
    EnzymeHumans

    Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). … Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580).

    Polypeptides: Inositol polyphosphate 4-phosphatase type IISynonyms: Type II inositol 3,4-bisphosphate 4-phosphatase