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Displaying results 4601 - 4610 of 10000 in total
  1. Drug

    Ezetimibe

    go.drugbank.com/drugs/DB00973
    ApprovedInvestigational

    [A15202] Ezetimibe is used as an adjunctive therapy to a healthy diet to lower cholesterol levels in primary hyperlipidemia, mixed hyperlipidemia, homozygous familial hypercholesterolemia (HoFH), and homozygous … Ezetimibe is a lipid-lowering compound that inhibits intestinal cholesterol and phytosterol absorption.

    Mixtures: TIAZOMET ® A 40/10 TABLETAS, LIPIVAN E ® 10 MG / 10 MGCategories: P-glycoprotein substrates, Cytochrome P-450 CYP2C8 Inhibitors
  2. Target

    Dehydrogenase/reductase SDR family member 4

    go.drugbank.com/bio_entities/BE0000032
    TargetHumans

    NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones

    Polypeptides: Dehydrogenase/reductase SDR family member 4Synonyms: Short-chain dehydrogenase/reductase family member 4
  3. Target

    Solute carrier family 12 member 4

    go.drugbank.com/bio_entities/BE0000601
    TargetTransporterHumans

    Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:35759661). May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912). May be involved in the regulation of ...

    Polypeptides: Solute carrier family 12 member 4
  4. Target

    Cobalt-precorrin-4 C(11)-methyltransferase

    go.drugbank.com/bio_entities/BE0001398
    TargetBacillus megaterium

    Catalyzes the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5A.

    Polypeptides: Cobalt-precorrin-4 C(11)-methyltransferaseFunction: precorrin-4 C11-methyltransferase activity
  5. Target

    4-cresol dehydrogenase [hydroxylating] flavoprotein subunit

    go.drugbank.com/bio_entities/BE0002978
    TargetPseudomonas putida

    Catalyzes the azurin dependent hydroxylation of the methyl group of 4-methylphenol to form 4-hydroxybenzaldehyde.

    Polypeptides: 4-cresol dehydrogenase [hydroxylating] flavoprotein subunitFunction: 4-cresol dehydrogenase (hydroxylating) activity
  6. Target

    DNA damage-inducible transcript 4 protein

    go.drugbank.com/bio_entities/BE0003445
    TargetHumans

    Plays a role in neuronal cell death … Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB.

    Polypeptides: DNA damage-inducible transcript 4 protein
  7. Target

    Trafficking protein particle complex subunit 4

    go.drugbank.com/bio_entities/BE0004278
    TargetHumans

    Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (PubMed:31794024). May play a role in dendrite postsynaptic membrane trafficking (By similarity) … Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase (Probable).

    Polypeptides: Trafficking protein particle complex subunit 4
  8. Target

    Serine/arginine-rich splicing factor 4

    go.drugbank.com/bio_entities/BE0009120
    TargetHumans

    Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10

    Polypeptides: Serine/arginine-rich splicing factor 4Synonyms: Splicing factor, arginine/serine-rich 4
  9. Target

    Neurogenic locus notch homolog protein 4

    go.drugbank.com/bio_entities/BE0010483
    TargetHumans

    Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. … Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.

    Polypeptides: Neurogenic locus notch homolog protein 4Synonyms: Notch 4
  10. Target

    Solute carrier family 4 member 11

    go.drugbank.com/bio_entities/BE0017156
    TransporterHumans

    In the presence of borate B(OH)4(-), acts as a voltage-dependent electrogenic Na(+)-coupled B(OH)4(-) cotransporter controlling boron homeostasis (PubMed:15525507). … In the absence of B(OH)4(-), acts as a Na(+)-coupled OH(-) or H(+) permeable channel with implications in cellular redox balance (PubMed:15525507, PubMed:28642546).

    Polypeptides: Solute carrier family 4 member 11