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Displaying results 4621 - 4630 of 10000 in total
  1. Target

    Receptor tyrosine-protein kinase erbB-4

    go.drugbank.com/bio_entities/BE0004772
    TargetHumans

    Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A … Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1.

    Polypeptides: Receptor tyrosine-protein kinase erbB-4Synonyms: Proto-oncogene-like protein c-ErbB-4
  2. Target

    Phosphatidylinositol 4-kinase type 2-beta

    go.drugbank.com/bio_entities/BE0008985
    TargetHumans

    The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5

    Polypeptides: Phosphatidylinositol 4-kinase type 2-betaSynonyms: Phosphatidylinositol 4-kinase type II-beta
  3. Target

    Heat shock 70 kDa protein 4

    go.drugbank.com/bio_entities/BE0009027
    TargetHumans

    Polypeptides: Heat shock 70 kDa protein 4
  4. Target

    MAP/microtubule affinity-regulating kinase 4

    go.drugbank.com/bio_entities/BE0009482
    TargetHumans

    Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). … Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667).

    Polypeptides: MAP/microtubule affinity-regulating kinase 4
  5. Target

    Inositol polyphosphate 4-phosphatase type II

    go.drugbank.com/bio_entities/BE0011457
    EnzymeHumans

    Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). … Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580).

    Polypeptides: Inositol polyphosphate 4-phosphatase type IISynonyms: Type II inositol 3,4-bisphosphate 4-phosphatase
  6. Target

    Taste receptor type 2 member 4

    go.drugbank.com/bio_entities/BE0020472
    TargetHumans

    Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRP...

    Polypeptides: Taste receptor type 2 member 4
  7. Target

    Neuropeptide Y receptor type 4-2

    go.drugbank.com/bio_entities/BE0024014
    TargetHumans

    G protein-coupled receptor for PPY/pancreatic polypeptide/PP, NPY/neuropeptide Y and PYY/peptide YY that is negatively coupled to cAMP. The rank order of affinity for these polypeptides and their derivatives is PP, PP (2-36) and [Ile-31,...

    Polypeptides: Neuropeptide Y receptor type 4-2
  8. Drug

    Solifenacin

    go.drugbank.com/drugs/DB01591
    ApprovedInvestigational

    Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. … [L7511] It has a long duration of action as it is usually taken once daily.[L7511] Solifenacin was granted FDA approval on 19 November 2004.[L7511]

    Mixtures: VESOMNİ 6 MG/0.4 MG DEĞİŞTİRİLMİŞ SALIMLI TABLET, 30 ADET, Vesomni 6 mg/0,4 mg Tabletten mit veränderter WirkstofffreisetzungCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 Substrates
  9. Target

    Potassium voltage-gated channel subfamily A member 1

    go.drugbank.com/bio_entities/BE0000781
    TargetHumans

    Plays a role in the reabsorption of Mg(2+) in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential (PubMed:19307729, PubMed:23903368 … Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception

    Polypeptides: Potassium voltage-gated channel subfamily A member 1
  10. Target

    HLA class I histocompatibility antigen, A alpha chain

    go.drugbank.com/bio_entities/BE0003483
    TargetHumans

    In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive

    Polypeptides: HLA class I histocompatibility antigen, A alpha chainSynonyms: HLA-A, MHC class I antigen A*3