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3-oxo-5-alpha-steroid 4-dehydrogenase 1
go.drugbank.com/bio_entities/BE0000539TargetEnzymeHumansCatalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed … Converts testosterone into 5-alpha-dihydrotestosterone (DHT), a more potent androgen as it is the preferred ligand for androgen receptor (AR) transactivation, making this reaction a key step in male sexual
Polypeptides: 3-oxo-5-alpha-steroid 4-dehydrogenase 1Function: 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activityATP-binding cassette sub-family C member 4
go.drugbank.com/bio_entities/BE0001188TransporterTargetHumansTransports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid … Transports a wide range of drugs and their metabolites. including anticancer, antiviral and antibiotic molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232).
Polypeptides: ATP-binding cassette sub-family C member 4Synonyms: Multidrug resistance-associated protein 44-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase
go.drugbank.com/bio_entities/BE0002977TargetClostridium aminobutyricumThe mechanism of the reaction seems to go through three steps: (1) the FAD-dependent oxidation of 4-hydroxybutyryl-CoA to 4-hydroxycrotonyl-CoA; (2) the hydroxyl group is substituted by a hydride derived … Catalyzes the reversible conversion of 4-hydroxybutyryl-CoA to crotonyl-CoA.
Polypeptides: 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomeraseSynonyms: 4-BUDH4-hydroxy-3-methylbut-2-enyl diphosphate reductase
go.drugbank.com/bio_entities/BE0004045TargetEscherichia coli (strain K12)Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).
Polypeptides: 4-hydroxy-3-methylbut-2-enyl diphosphate reductaseSynonyms: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductaseMitogen-activated protein kinase kinase kinase kinase 4
go.drugbank.com/bio_entities/BE0009473TargetHumansActivator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. … Serine/threonine kinase that plays a role in the response to environmental stress and cytokines such as TNF. Appears to act upstream of the JUN N-terminal pathway (PubMed:9890973).
Polypeptides: Mitogen-activated protein kinase kinase kinase kinase 4Synonyms: MEKKK 4, MEK kinase kinase 4Dual specificity mitogen-activated protein kinase kinase 4
go.drugbank.com/bio_entities/BE0010122TargetHumansDual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2...
Polypeptides: Dual specificity mitogen-activated protein kinase kinase 4Synonyms: MEK 4, MAPKK 4Manidipine
go.drugbank.com/drugs/DB09238ApprovedInvestigationalWithdrawnManidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. … It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: MANIDIPINA EG, IPERTEN 20 MG TABLET, 28 ADETPravastatin
go.drugbank.com/drugs/DB00175ApprovedInvestigational[L6142] Pravastatin is made through a fermentation process in which [mevastatin] is first obtained. … It was the first statin administered as the active form and not as a prodrug.[T274] This drug was developed by Sankyo Co.
Mixtures: PRAVAFEN® CAPSULASCategories: P-glycoprotein substratesLincomycin
go.drugbank.com/drugs/DB01627ApprovedInvestigationalVet approvedLincomycin is a lincosamide antibiotic first isolated from the soil bacterium _Streptomyces lincolnensis_ in Lincoln, Nebraska. … [A190621] Clinical use of lincomycin has largely been superseded by its semisynthetic derivative [clindamycin] due to its higher efficacy and a wider range of susceptible organisms, though lincomycin remains
Categories: Heterocyclic Compounds, 1-RingProducts: LINCOCIN 2 ML 600 MG 1 AMPUL, LINKAMIN ENJEKTABL 600 MG/2 ML, 1 ADETTenofovir disoproxil
go.drugbank.com/drugs/DB00300ApprovedInvestigationalTenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase … This drug is prescribed in combination with other drugs for the management of HIV infection as well as for Hepatitis B therapy. Tenofovir disoproxil was initially approved in 2001 [FDA label].
Mixtures: TENOHOPE E (EMTRICITABINE 200 MG & TENOFOVIR DISOPROXIL FUMARATE 300 MG TABLETS), EMTRICITABINA E TENOFOVIR DISOPROXIL EGCategories: P-glycoprotein inhibitors, P-glycoprotein substrates