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Proteasome subunit alpha type-2
go.drugbank.com/bio_entities/BE0003911TargetHumansComponent of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associat...
Polypeptides: Proteasome subunit alpha type-2Synonyms: alpha-2, Proteasome subunit alpha-2Immunoglobulin heavy variable 1-2
go.drugbank.com/bio_entities/BE0004264TargetHumansV region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocy...
Polypeptides: Immunoglobulin heavy variable 1-2Polycystin-2-like protein 1
go.drugbank.com/bio_entities/BE0008712TransporterHumansThe homomeric and heteromeric channels formed by PKD1L2 and PKD1L3 are activated by low pH and Ca(2+), but opens only when the extracellular pH rises again and after the removal of acid stimulus (PubMed
Polypeptides: Polycystin-2-like protein 1Synonyms: Polycystin-2 homolog, Polycystic kidney disease 2-like 1 proteinCyclin-dependent kinase-like 2
go.drugbank.com/bio_entities/BE0009423TargetHumansPolypeptides: Cyclin-dependent kinase-like 2eIF-2-alpha kinase GCN2
go.drugbank.com/bio_entities/BE0009435TargetHumansMetabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545 … EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to
Polypeptides: eIF-2-alpha kinase GCN2Synonyms: Eukaryotic translation initiation factor 2-alpha kinase 4Inward rectifier potassium channel 2
go.drugbank.com/bio_entities/BE0009710TargetHumansInward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:36149965, PubMed:7590287, PubMed:9490857). Their voltage dependence is regulated by the co...
Polypeptides: Inward rectifier potassium channel 2Synonyms: Potassium channel, inwardly rectifying subfamily J member 2Free fatty acid receptor 2
go.drugbank.com/bio_entities/BE0010131TargetHumansG protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omni...
Polypeptides: Free fatty acid receptor 2Bcl-2-related protein A1
go.drugbank.com/bio_entities/BE0010682TargetHumansRetards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). Can inhibit apoptosis induced by serum starvat...
Polypeptides: Bcl-2-related protein A1Synonyms: Bcl-2-like protein 5Leukocyte cell-derived chemotaxin-2
go.drugbank.com/bio_entities/BE0011408TargetHumansHas a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921)
Polypeptides: Leukocyte cell-derived chemotaxin-2Synonyms: LECT-2Vasoactive intestinal polypeptide receptor 2
go.drugbank.com/bio_entities/BE0013151TargetHumansG protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:7811244, PubMed:35477937, PubMed:8933357). Binds VIP and both PA...
Polypeptides: Vasoactive intestinal polypeptide receptor 2Synonyms: VIP-R-2