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Avelumab
go.drugbank.com/drugs/DB11945ApprovedInvestigationalAvelumab is a human IgG1 lambda monoclonal antibody that binds programmed cell death ligand-1 (PD-L1) to block its interaction with its receptors found on T cells and antigen-presenting cells. … [A261496] Avelumab was first approved by the FDA on March 23, 2017.
Categories: PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsProducts: BAVENCIO 200 MG/10 ML IV İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 FLAKON, BAVENCIO®Cysteamine
go.drugbank.com/drugs/DB00847ApprovedInvestigationalCystinosis is a rare disease caused by mutations in the CTNS gene that encodes for cystinosin, a protein responsible for transporting cystine out of the cell lysosome. … [L15611] On August 25th 2020, the first ophthalmic solution for cystinosis requiring only 4 daily treatments was granted FDA approval.
Synonyms: 2-amino-1-ethanethiol, β-MEAProducts: CYSTAGON ® 150 MG, CYSTAGON ® 50 MG CAPSULASAnakinra
go.drugbank.com/drugs/DB00026ApprovedInvestigationalAnakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. … A few studies have evaluated the use of anakinra for the treatment of coronavirus disease 2019 (COVID-19).
Synonyms: Interleukin-1 receptor antagonist anakinraCategories: Interleukin-1 Receptor AntagonistFelbamate
go.drugbank.com/drugs/DB00949ApprovedAlternatively, it is used to treat partial and generalized seizures associated with Lennox-Gastaut syndrome in children. It has a weak inhibitory effect on GABA receptor binding sites. … Felbamate is an anticonvulsant drug used in the treatment of epilepsy. In particular, in the adult patient population, it can be employed to treat partial seizures (with and without generalization).
Synonyms: Carbamic acid 3-carbamoyloxy-2-phenyl-propyl ester, 2-phenyl-1,3-propanediol dicarbamateCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersIdursulfase
go.drugbank.com/drugs/DB01271ApprovedInvestigationalIdursulfase is a purified form of human iduronate-2-sulfatase, a lysosomal enzyme. Idursulfase is produced by recombinant DNA technology in a human cell line. … Idursulfase is a 525-amino acid glycoprotein with a molecular weight of approximately 76 kilodaltons.
Synonyms: Iduronate 2-sulfatase, Alpha-L-iduronate sulfate sulfataseProducts: ELAPRASE 2 MG/ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET, ELAPRASE ®Roflumilast
go.drugbank.com/drugs/DB01656ApprovedInvestigationalRoflumilast is a highly selective phosphodiesterase-4 (PDE4) inhibitor. … [A251385] PDE4 is a major cyclic-3',5′-adenosinemonophosphate (cyclic AMP, cAMP)-metabolizing enzyme [L37564] expressed on nearly all immune and pro-inflammatory cells, in addition to structural cells
Categories: Phosphodiesterase 4 Inhibitors, Cytochrome P-450 SubstratesProducts: DAXAS®, ROFLUNG 0,5 MG SAŞE ,30 SAŞEAminophylline
go.drugbank.com/drugs/DB01223ApprovedInvestigationalAminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. … Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator.
Categories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexProducts: TECAR 240 MG/10 ML IV INFUZYONLUK COZELTI, 6 ADET, AMINOPHYLLINE INJECTION 0.25 g/10 mlIntermittent distinct from a patient’s usual seizure pattern, stereotypic episode Epileptic seizure
go.drugbank.com/conditions/DBCOND0120023Drugs: DiazepamSynonyms: Intermittent distinct from a patient’s usual seizure pattern, stereotypic episode Epileptic seizureSolute carrier family 2, facilitated glucose transporter member 4
go.drugbank.com/bio_entities/BE0000893TransporterTargetHumansInsulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation.
Polypeptides: Solute carrier family 2, facilitated glucose transporter member 4Synonyms: GLUT-4, Glucose transporter type 4, insulin-responsivePotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
go.drugbank.com/bio_entities/BE0021454TargetHumansHyperpolarization-activated ion channel that are permeable to Na(+) and K(+) ions with very slow activation and inactivation (PubMed:10228147, PubMed:10430953, PubMed:20829353). Exhibits higher selectivity for K(+) over Na(+) ions (PubMe...
Polypeptides: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4