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Ivermectin
go.drugbank.com/drugs/DB00602ApprovedInvestigationalVet approved[L31453] Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1a</sub>) and 10% 5-O-demethyl-25-de … (1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)avermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1b</sub>).
Mixtures: Heartgard Plus Chewable Tablet for Dogs - 51 - 100 lbs, Heartgard Plus Chewable Tablet for Dogs - 26 - 50 lbsCategories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 SubstratesCephalexin
go.drugbank.com/drugs/DB00567ApprovedInvestigationalVet approved[A179071,A179074] This antibiotic contains a beta lactam and a dihydrothiazide. … [A179071] Cephalexin is used to treat a number of susceptible bacterial infections through inhibition of cell wall synthesis.[A179083,L6547] Cephalexin was approved by the FDA on 4 January 1971.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesInternational brands: L-KeflexAnakinra
go.drugbank.com/drugs/DB00026ApprovedInvestigationalAnakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. … A few studies have evaluated the use of anakinra for the treatment of coronavirus disease 2019 (COVID-19).
Products: Kıneret 100 mg/ 0.67 ml Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Enjektör, 7 ADET, Kıneret 100 mg/ 0.67 ml Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Enjektör, 28 ADETPalivizumab
go.drugbank.com/drugs/DB00110ApprovedInvestigationalSynagis is a composite of human (95%) and murine (5%) antibody sequences. … Palivizumab is expressed from a stable murine (mouse) myeloma cell line (NS0).
Products: SYNAGIS® 50 MG, SYNAGIS®100 MG SOLUCION PARA INYECCIÓNMegestrol acetate
go.drugbank.com/drugs/DB00351ApprovedInvestigationalVet approvedA progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: MGAMethotrimeprazine
go.drugbank.com/drugs/DB01403ApprovedA phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsSynonyms: (-)-10-(3-(Dimethylamino)-2-methylpropyl)-2-methoxyphenothiazine, (-)-(2R)-3-(2-methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amineCyclobenzaprine
go.drugbank.com/drugs/DB00924ApprovedInvestigationalCyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961[A185039] and has been available for human use since 1977. … [A184982] It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.
Mixtures: Cyclo/Gaba 10/300 Pack, Cyclo/MagCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesAlemtuzumab
go.drugbank.com/drugs/DB00087ApprovedInvestigationalThe Campath-1H antibody is an IgG1 kappa with the human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody (Campath-1G). … The dose of alemtuzumab used for B-CLL is much higher than that for MS, and also at more frequent dosing.[L43397, L30335]
Products: MABCAMPATH INF SOL ICIN 30 MG/ML KONS 1 ML 3 FLK (10 MG/ML KONSANTRE 3 AMP), MABCAMPATH ® 30 MG/MLHydromorphone
go.drugbank.com/drugs/DB00327ApprovedIllicitInvestigationalHydromorphone is a pure opioid,[A176468] a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. … Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 and 8.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesProducts: Hydal 10 mg/ml Injektions-/Infusionslösung, Hydagelan 10 mg/ml Injektions-/InfusionslösungDimethyl fumarate
go.drugbank.com/drugs/DB08908ApprovedInvestigationalDimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate deg...
Products: Dimethylfumarat 1A Pharma 120 mg - magensaftresistente Hartkapseln, Dimethylfumarat 1A Pharma 120 mg – magensaftresistente Hartkapseln