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Proton-coupled amino acid transporter 2
go.drugbank.com/bio_entities/BE0004704TransporterHumansElectrogenic proton/amino acid symporter with a high selectivity for the small side chains amino acids glycine, alanine and proline, where both L- and D-enantiomers are transported. Extension of the backbone length, as in beta-alanine an...
Polypeptides: Proton-coupled amino acid transporter 2Synonyms: Proton/amino acid transporter 2, Solute carrier family 36 member 2Natural resistance-associated macrophage protein 2
go.drugbank.com/bio_entities/BE0008685TransporterTargetHumansSelectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (PubMed:17109629, PubMed:17293870, PubMed:22736759, PubMed:25326704 … Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (By similarity).
Polypeptides: Natural resistance-associated macrophage protein 2Synonyms: NRAMP 2, Solute carrier family 11 member 2High molecular weight rhoptry protein 2
go.drugbank.com/bio_entities/BE0009195TargetPlasmodium falciparum (isolate 3D7)Participates in the formation of new permeability pathways in Plasmodium-infected erythrocytes enabling the uptake of nutrients from the blood plasma (PubMed:28252383). Required for maintaining invasion capacity of merozoites (PubMed:282...
Polypeptides: High molecular weight rhoptry protein 245 kDa immediate-early protein 2
go.drugbank.com/bio_entities/BE0009327TargetHuman cytomegalovirus (strain Towne)Activates the E1.7 promoter. This activation is augmented by the IE1 protein. It down-regulates the transcription of genes under the control of the major IE promoter.
Polypeptides: 45 kDa immediate-early protein 2Serine/threonine-protein kinase PAK 2
go.drugbank.com/bio_entities/BE0009506TargetHumansSerine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed...
Polypeptides: Serine/threonine-protein kinase PAK 2Synonyms: PAK-2, p21-activated kinase 2NAD-dependent protein deacetylase sirtuin-2
go.drugbank.com/bio_entities/BE0009759TargetHumansNAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, Pub...
Polypeptides: NAD-dependent protein deacetylase sirtuin-2Synonyms: SIR2-like protein 2, Regulatory protein SIR2 homolog 2Solute carrier family 23 member 2
go.drugbank.com/bio_entities/BE0009869TransporterTargetHumansMediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed:10471399)
Polypeptides: Solute carrier family 23 member 2Synonyms: Na(+)/L-ascorbic acid transporter 2, Yolk sac permease-like molecule 2Programmed cell death 1 ligand 2
go.drugbank.com/bio_entities/BE0010315TargetHumansPlays a critical role in induction and maintenance of immune tolerance to self (PubMed:11224527, PubMed:12538684). Acts as a ligand for the inhibitory receptor PDCD1/PD-1, inhibiting T-cell proliferation by blocking cell cycle progressio...
Polypeptides: Programmed cell death 1 ligand 2Synonyms: PD-1 ligand 2, PDCD1 ligand 2Nuclear cap-binding protein subunit 2
go.drugbank.com/bio_entities/BE0013483TargetHumansComponent of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated ge...
Polypeptides: Nuclear cap-binding protein subunit 2Neurogenic locus notch homolog protein 2
go.drugbank.com/bio_entities/BE0013939TargetHumansFunctions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination.
Polypeptides: Neurogenic locus notch homolog protein 2Synonyms: Notch 2