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Displaying results 5081 - 5090 of 10000 in total
  1. Target

    Glutamyl aminopeptidase

    go.drugbank.com/bio_entities/BE0002271
    TargetHumans

    Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II

    Synonyms: AP-A, Aminopeptidase A
  2. Drug

    Lorazepam

    go.drugbank.com/drugs/DB00186
    ApprovedInvestigational

    Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. … [A957] It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977.

    Synonyms: o-Chloroxazepam, o-ChlorooxazepamProducts: LORAZEPAM EG, ATIVAN® 1 MG TABLETAS
  3. Drug

    Nepidermin

    go.drugbank.com/drugs/DB14145
    Investigational

    Synonyms: H-EGFInternational brands: Regen-D
  4. Target

    Uncharacterized MFS-type transporter EfpA

    go.drugbank.com/bio_entities/BE0009715
    TargetMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

    Synonyms: Efflux protein A
  5. Drug

    Tobramycin

    go.drugbank.com/drugs/DB00684
    ApprovedInvestigational

    [L32744, L32749] Its use is limited in some cases by characteristic toxicities such as nephrotoxicity and ototoxicity, yet it remains a valuable option in the face of growing resistance to front-line antibiotics … [A232294, A232349, L32739, L32749] Tobramycin was approved by the FDA in 1975 and is currently available in a variety of forms for administration by inhalation, injection, and external application to

    Synonyms: O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine, 3'-Deoxykanamycin BMixtures: TOBRAMICINA E DESAMETASONE EG, TOBRAMICINA E DESAMETASONE DOC GENERICI
  6. Indication

    Fever

    go.drugbank.com/conditions/DBCOND0020923
    Drugs: Acetaminophen · Acetylsalicylic acid · Ascorbic acid · Brompheniramine · Caffeine · Chlorpheniramine +20 more
    Synonyms: Has a temperature
  7. Drug

    Febuxostat

    go.drugbank.com/drugs/DB04854
    ApprovedInvestigational

    [A230548] In February 2019, a black box warning for febuxostat was added, based on the findings of a post-market clinical study (the CARES trial) where there was an increased risk of cardiovascular … Febuxostat is a non-purine xanthine oxidase (XO) inhibitor.

    Synonyms: 2-(3-cyano-4-isobutoxyphenyl)-4-methyl- 1,3-thiazole-5-carboxylic acidCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates
  8. Drug

    Fingolimod

    go.drugbank.com/drugs/DB08868
    ApprovedInvestigational

    [A176474] Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. … Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects.

    Categories: P-glycoprotein inducers, Cytochrome P-450 SubstratesProducts: FINGOLIMOD EG, DROPTON®
  9. Drug

    Levofloxacin

    go.drugbank.com/drugs/DB01137
    ApprovedInvestigational

    Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. … [L11638] Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones

    Synonyms: L-Ofloxacin, (S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylic acidCategories: 4-Quinolones, MATE 1 Inhibitors
  10. Drug

    Teriflunomide

    go.drugbank.com/drugs/DB08880
    ApprovedInvestigational

    Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. … The FDA label states an important warning about the risk of hepatoxicity and teratogenicity for patients using teriflunomide.

    Synonyms: (Z)-2-cyano-alpha,alpha,alpha-trifluoro-3-hydroxy-p-crotonotoluidideCategories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme Inducers