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Phosphatidylinositol 4-kinase type 2-beta
go.drugbank.com/bio_entities/BE0008985TargetHumansTogether with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell (PubMed:11923287, PubMed:12324459). This contribution may be especially significant in plasma membrane, endosom...
Polypeptides: Phosphatidylinositol 4-kinase type 2-betaTaste receptor type 2 member 16
go.drugbank.com/bio_entities/BE0009016TargetHumansGustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5
Polypeptides: Taste receptor type 2 member 16Keratin, type II cytoskeletal 2 epidermal
go.drugbank.com/bio_entities/BE0009063TargetHumansStructural component of intermediate filaments in suprabasal keratinocytes of stratified epidermis. Forms heteropolymers with type I keratins (e.g., KRT10), assembling into keratin intermediate filament networks that support mechanical i...
Polypeptides: Keratin, type II cytoskeletal 2 epidermalSynonyms: Keratin-2 epidermisBone morphogenetic protein receptor type-2
go.drugbank.com/bio_entities/BE0009324TargetHumansOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SM...
Polypeptides: Bone morphogenetic protein receptor type-2Synonyms: BMPR-2, BMP type-2 receptor30 kDa immediate-early protein 2
go.drugbank.com/bio_entities/BE0009326TargetHuman cytomegalovirus (strain Towne)Activates the E1.7 promoter. This activation is augmented by the IE1 protein. It down-regulates the transcription of genes under the control of the major IE promoter.
Polypeptides: 30 kDa immediate-early protein 2NUAK family SNF1-like kinase 2
go.drugbank.com/bio_entities/BE0009503TargetEnzymeHumansStress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF, via NF-kappa-B. Protects cells from CD95-mediated apopto...
Polypeptides: NUAK family SNF1-like kinase 2Synonyms: Omphalocele kinase 2Y+L amino acid transporter 2
go.drugbank.com/bio_entities/BE0009872TransporterHumansHeterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and is...
Polypeptides: Y+L amino acid transporter 2Synonyms: y+LAT-2, y(+)L-type amino acid transporter 2Tumor-associated calcium signal transducer 2
go.drugbank.com/bio_entities/BE0009918TargetHumansMay function as a growth factor receptor
Polypeptides: Tumor-associated calcium signal transducer 2Synonyms: Cell surface glycoprotein Trop-2Hepatitis A virus cellular receptor 2
go.drugbank.com/bio_entities/BE0010551TargetHumansIn CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion.
Polypeptides: Hepatitis A virus cellular receptor 2Synonyms: HAVcr-2Acyl-coenzyme A thioesterase 2, mitochondrial
go.drugbank.com/bio_entities/BE0013225EnzymeHumansCatalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:10944470, PubMed:16940157). Displays higher activity toward long chain acyl CoAs (C14-C20) (PubM...
Polypeptides: Acyl-coenzyme A thioesterase 2, mitochondrialSynonyms: Acyl-CoA thioesterase 2, Long-chain acyl-CoA thioesterase 2