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2-oxoglutarate dehydrogenase complex component E1
go.drugbank.com/bio_entities/BE0000162TargetHumansCan catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate (PubMed:28435050). … 2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC) (PubMed:24495017, PubMed:25210035, PubMed:28435050).
Polypeptides: 2-oxoglutarate dehydrogenase complex component E1Synonyms: 2-oxoglutarate dehydrogenase, mitochondrial, Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenasePotassium channel subfamily K member 2
go.drugbank.com/bio_entities/BE0000210TargetHumansK(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens t...
Polypeptides: Potassium channel subfamily K member 2Anti-Muellerian hormone type-2 receptor
go.drugbank.com/bio_entities/BE0000675TargetHumansOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SM...
Polypeptides: Anti-Muellerian hormone type-2 receptorNeuronal acetylcholine receptor subunit alpha-2
go.drugbank.com/bio_entities/BE0000738TargetHumansComponent of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collecti...
Polypeptides: Neuronal acetylcholine receptor subunit alpha-2Synonyms: Nicotinic acetylcholine receptor subunit alpha-2Cellular retinoic acid-binding protein 2
go.drugbank.com/bio_entities/BE0000782CarrierTransporterHumansTransports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors
Polypeptides: Cellular retinoic acid-binding protein 2Solute carrier family 15 member 2
go.drugbank.com/bio_entities/BE0001134TransporterTargetHumansTransports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1 (By similarity). … Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:16434549, PubMed:18367661, PubMed:7756356).
Polypeptides: Solute carrier family 15 member 2Synonyms: Peptide transporter 2MAP kinase-activated protein kinase 2
go.drugbank.com/bio_entities/BE0001373TargetHumansPhosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue.
Polypeptides: MAP kinase-activated protein kinase 2Synonyms: MK-2, MAPKAPK-2Ecto-NOX disulfide-thiol exchanger 2
go.drugbank.com/bio_entities/BE0002434TargetHumansMay be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide...
Polypeptides: Ecto-NOX disulfide-thiol exchanger 21,4-Dihydroxy-2-naphthoyl-CoA synthase
go.drugbank.com/bio_entities/BE0002684TargetMycobacterium tuberculosisConverts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
Polypeptides: 1,4-dihydroxy-2-naphthoyl-CoA synthaseFunction: 1,4-dihydroxy-2-naphthoyl-CoA synthase activityCasein kinase I isoform gamma-2
go.drugbank.com/bio_entities/BE0003334TargetHumansSerine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling ...
Polypeptides: Casein kinase I isoform gamma-2Synonyms: CKI-gamma 2