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Geranylgeranyl transferase type-2 subunit beta
go.drugbank.com/bio_entities/BE0004073TargetHumansCatalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A (PubMed:7991565). Catalytic su...
Polypeptides: Geranylgeranyl transferase type-2 subunit betaAmyloid beta precursor like protein 2
go.drugbank.com/bio_entities/BE0009093TargetHumansMay play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits...
Polypeptides: Amyloid beta precursor like protein 2Synonyms: APLP-2, Amyloid-like protein 2Far upstream element-binding protein 2
go.drugbank.com/bio_entities/BE0009095TargetHumansBinds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that ...
Polypeptides: Far upstream element-binding protein 2Synonyms: FUSE-binding protein 25,6-dihydroxyindole-2-carboxylic acid oxidase
go.drugbank.com/bio_entities/BE0010503TargetHumansCatalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+) (PubMed:28661582
Polypeptides: 5,6-dihydroxyindole-2-carboxylic acid oxidaseC-X-C motif chemokine 2
go.drugbank.com/bio_entities/BE0010525TargetHumansProduced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoi...
Polypeptides: C-X-C motif chemokine 2Synonyms: Macrophage inflammatory protein 2-alphaBaculoviral IAP repeat-containing protein 2
go.drugbank.com/bio_entities/BE0010675TargetHumansMulti-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ...
Polypeptides: Baculoviral IAP repeat-containing protein 2Synonyms: hIAP-2, Inhibitor of apoptosis protein 2Cyclic nucleotide-gated channel alpha-2
go.drugbank.com/bio_entities/BE0014924TargetHumansThe rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for … Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization.
Polypeptides: Cyclic nucleotide-gated channel alpha-2Synonyms: CNG-2, CNG channel alpha-2Potassium channel subfamily T member 2
go.drugbank.com/bio_entities/BE0015626TargetHumansSodium-activated and chloride-activated potassium channel (PubMed:14684870, PubMed:16687497, PubMed:25214519, PubMed:27682982, PubMed:29069600, PubMed:29740868). Produces rapidly activating outward rectifier K(+) currents (PubMed:1468487...
Polypeptides: Potassium channel subfamily T member 2Interleukin-12 receptor subunit beta-2
go.drugbank.com/bio_entities/BE0018860TargetHumansReceptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly en...
Polypeptides: Interleukin-12 receptor subunit beta-2Synonyms: IL-12R-beta-2, IL-12R subunit beta-2Taste receptor type 2 member 10
go.drugbank.com/bio_entities/BE0020463TargetHumansGustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5
Polypeptides: Taste receptor type 2 member 10Synonyms: Taste receptor family B member 2