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Clevidipine
go.drugbank.com/drugs/DB04920ApprovedInvestigationalClevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not an option.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersProducts: Cleviprex 0,5 mg/ml Emulsion zur InjektionAcylcarnitine (2Z)-2-(propan-2-yl)but-2-enedioylcarnitine
smpdb.ca/view/SMP0123554Metabolic(2Z)-2-(propan-2-yl)but-2-enedioylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, (2Z)-2-(propan-2-yl)but-2-enedioyl-CoA reacts with L-carnitine to form (2Z)-2-(propan-2-yl)but-2-enedioylcarnitine.
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreEnzymes: Carnitine O-palmitoyltransferase 2, mitochondrialErgoloid mesylate
go.drugbank.com/drugs/DB01049Approved[A32912] All these components are produced by the fungus _Claviceps purpurea_ and are all derivatives of the tetracyclic compound 6-methylergonovine. … [A32914] The mixture of ergoloid mesylate was first developed by Novartis and FDA approved on November 5, 1953, but this specific formulation is now discontinued.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: SEGOL 1 MG/ML DAMLA, ÇÖZELTİ, 50 ML, อินเดอร์จิน 1 มก.Hydroxocobalamin
go.drugbank.com/drugs/DB00200ApprovedInvestigationalHydroxocobalamin, also known as vitamin B12a and hydroxycobalamin, is an injectable form of vitamin B 12 that has been used therapeutically to treat vitamin B 12 deficiency.
Mixtures: ENJEKSİYONLUK ÇÖZELTİ, 50 AMPUL (25+25), TRIBEDOCE C/LCategories: Vitamin B Complex, Heterocyclic Compounds, 1-RingFelodipine
go.drugbank.com/drugs/DB01023ApprovedFelodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. … In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent
Mixtures: DELMUNO 5/5 MG, DELIX DUO 5 MG/5 MG FİLM KAPLI TABLET, 30 ADETCategories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesDaptomycin
go.drugbank.com/drugs/DB00080ApprovedInvestigational[A231379, A231384, L32534] Chemically, daptomycin comprises 13 amino acids, including several non-standard and D-amino acids, with the C-terminal 10 amino acids forming an ester-linked ring and the N-terminal … [A231379] Daptomycin was approved by the FDA on September 12, 2003, and is marketed under the name CUBICIN® by Cubist Pharmaceuticals LLC (Merck & Co.).[L32534]
Categories: P-glycoprotein substratesProducts: DATABIN® 500 MG, DATOCIN® 500 MG POLVO LIOFILIZADOValdecoxib
go.drugbank.com/drugs/DB00580ApprovedWithdrawnValdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke.
Categories: COX-2 Inhibitors, Selective Cyclooxygenase 2 Inhibitors (NSAIDs)Products: BEXTRA®20 MG TABLETAS RECUBIERTAS, VALDYNE 20 MG TABLETAS RECUBIERTASRamelteon
go.drugbank.com/drugs/DB00980ApprovedInvestigationalRamelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: RAMELDA 8 MG FILM KAPLI TABLET,30 ADET, ROZEREST 8 MG FİLM KAPLI TABLET, 10 ADETOzanimod
go.drugbank.com/drugs/DB12612ApprovedInvestigational[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. … Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease.
Mixtures: ZEPOSIA 7-Day Starter Pack, ZEPOSIA 7-Day Starter PackCategories: Cytochrome P-450 Substrates, P-glycoprotein substrates2-Aminoadipic 2-Oxoadipic Aciduria
smpdb.ca/view/SMP0000719Disease2-Aminoadipic 2-oxoadipic aciduria is a disorder of lysine metabolism caused by a defective DHTKD1 gene. … This disease is characterized by a large accumulation of 2-oxoadipate and 2-hydroxyadipate in the urine.
Drugs: Pyridoxal phosphate · Lysine · Glutamic acid · NADH · Oxogluric acid · Flavin adenine dinucleotide +1 moreEnzymes: Mitochondrial ornithine transporter 2, Low affinity cationic amino acid transporter 2