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Displaying results 5421 - 5430 of 10000 in total
  1. Drug

    Cilazapril

    go.drugbank.com/drugs/DB01340
    ApprovedInvestigational

    It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat. … It is branded as Inhibace in Canada and other countries, Vascace and Dynorm in a number of European countries, among many other names. None of these varieties are available in the United States.

    Mixtures: İNHİBACE PLUS 5 MG/12,5 MG FILM KAPLI TABLET, 28 ADET, INHIBACE PLUS 5 MG TABLET, 28 ADETCategories: P-glycoprotein inhibitors, Heterocyclic Compounds, 1-Ring
  2. Drug

    Brigatinib

    go.drugbank.com/drugs/DB12267
    ApprovedInvestigational

    [A31313] Brigatinib was developed by Ariad Pharmaceuticals, a subsidiary of Takeda Pharmaceutical Company Limited, and FDA-approved on April 28, 2017.[L1026] … [A31311] It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the EML4-ALK fusion gene, which is a pivotal player in the transformation of susceptible lung parenchyma.

    Mixtures: ALUNBRİG 90 MG VE 180 MG FİLM KAPLI TABLET TEDAVİYE BAŞLANGIÇ PAKETİ, 7 ADET 90 MG VE 21 ADET 180 MG, ALUNBRİG 90 MG VE 180 MG FİLM KAPLI TABLET TEDAVİYE BAŞLANGIÇ PAKETİ, 7 ADET 90 MG VE 21 ADET 180 MGCategories: MATE 2 Inhibitors, Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index
  3. Target

    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

    go.drugbank.com/bio_entities/BE0000427
    TargetHumans

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The ...

    Polypeptides: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
  4. Target

    Voltage-dependent calcium channel subunit alpha-2/delta-1

    go.drugbank.com/bio_entities/BE0000691
    TargetHumans

    The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (PubMed:35293990).

    Polypeptides: Voltage-dependent calcium channel subunit alpha-2/delta-1Synonyms: Voltage-gated calcium channel subunit alpha-2/delta-1
  5. Target

    2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase

    go.drugbank.com/bio_entities/BE0002742
    TargetPseudomonas fluorescens

    Polypeptides: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase
  6. Target

    2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase

    go.drugbank.com/bio_entities/BE0003969
    TargetBurkholderia xenovorans (strain LB400)

    Catalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2-hydroxy-2,4-pentadienoic acid (HPD).

    Polypeptides: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase
  7. Target

    Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

    go.drugbank.com/bio_entities/BE0004631
    TargetHumans

    Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) an...

    Polypeptides: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2Synonyms: BCNG-2, Brain cyclic nucleotide-gated channel 2
  8. Target

    Solute carrier family 2, facilitated glucose transporter member 9

    go.drugbank.com/bio_entities/BE0004783
    TransporterHumans

    High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules (PubMed:18327257, PubMed:18701466, PubMed:22647630, PubMed:28083649, PubMed:36749388). May have a residual high-affinity, low-capacity g...

    Polypeptides: Solute carrier family 2, facilitated glucose transporter member 9
  9. Target

    Solute carrier family 2, facilitated glucose transporter member 5

    go.drugbank.com/bio_entities/BE0005216
    TransporterHumans

    Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine (By similarity).

    Polypeptides: Solute carrier family 2, facilitated glucose transporter member 5
  10. Target

    Solute carrier family 2, facilitated glucose transporter member 6

    go.drugbank.com/bio_entities/BE0005217
    TransporterHumans

    Probable sugar transporter that acts as a regulator of glycolysis in macrophages (Probable). Does not transport glucose (PubMed:30431159)

    Polypeptides: Solute carrier family 2, facilitated glucose transporter member 6