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Displaying results 551 - 560 of 661 in total
  1. Drug

    Phenaridine

    go.drugbank.com/drugs/DB09178
    ExperimentalIllicit

    Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue

  2. Drug

    Tepotinib

    go.drugbank.com/drugs/DB15133
    ApprovedInvestigational

    In February 2022, tepotinib was approved for use in Europe.[L42200]

  3. Drug

    Linaclotide

    go.drugbank.com/drugs/DB08890
    ApprovedInvestigational

    Linaclotide is a synthetic 14-amino acid cyclic peptide and first-in-class guanylate cyclase-C (G-CC) agonist. Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide hormones that are endogenous activato...

  4. Target

    NF-kappa-B inhibitor alpha

    go.drugbank.com/bio_entities/BE0003469
    TargetHumans

    Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:1493333, PubMed:36651806, PubMed:7479976). On cellular stimu...

    Synonyms: Major histocompatibility complex enhancer-binding protein MAD3
  5. Drug

    Ocrelizumab

    go.drugbank.com/drugs/DB11988
    ApprovedInvestigational

    [L42895] It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. … [L1199] In phase 3 clinical trials of patients with PPMS, treatment with ocrelizumab led to lower clinical and MRI progression rates compared to placebo.

  6. Target

    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

    go.drugbank.com/bio_entities/BE0000213
    TargetHumans

    Required for proper complex I assembly (PubMed:30245030). Complex I functions in the transfer of electrons from NADH to the respiratory chain. … Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis.

    Synonyms: Complex I-B14
  7. Target

    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

    go.drugbank.com/bio_entities/BE0000596
    TargetHumans

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

    Synonyms: Complex I-B22
  8. Target

    Proteasome subunit alpha type-5

    go.drugbank.com/bio_entities/BE0003914
    TargetHumans

    Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)

    Synonyms: Multicatalytic endopeptidase complex zeta chain
  9. Target

    Proteasome subunit alpha

    go.drugbank.com/bio_entities/BE0003353
    TargetMycobacterium tuberculosis

    Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. … In complex with the ATPase Mpa, degrades protein targets conjugated to a prokaryotic ubiquitin-like protein (Pup).

    Synonyms: Proteasome core protein PrcA
  10. Target

    Proteasome subunit beta

    go.drugbank.com/bio_entities/BE0004188
    TargetMycobacterium tuberculosis

    Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. … In complex with the ATPase Mpa, degrades protein targets conjugated to a prokaryotic ubiquitin-like protein (Pup).

    Synonyms: Proteasome core protein PrcB