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Displaying results 551 - 560 of 10000 in total
  1. Drug

    Iluzanebart

    go.drugbank.com/drugs/DB18275
    Investigational

    Synonyms: Immunoglobulin G1 [296-cysteine,301-glycine,306-cysteine], anti-(human triggering receptor expressed on myeloid cells 2) (human monoclonal VGL101 γ1-chain), disulfide with human monoclonal VGL101 κ-chain
  2. Drug

    Benzoic acid

    go.drugbank.com/drugs/DB03793
    ApprovedInvestigational

    This leads to excretion of these amino acids and a decrease in ammonia levels. Recent research shows that sodium benzoate may be beneficial as an add-on therapy (1 gram/day) in schizophrenia. … It is conjugated to GLYCINE in the liver and excreted as hippuric acid.

  3. Target

    Adenosine receptor A1

    go.drugbank.com/bio_entities/BE0000013
    TargetHumans

    Receptor for adenosine (PubMed:29925945). The activity of this receptor is mediated by G proteins such as GNAI2 which inhibit adenylyl cyclase

    Polypeptides: Adenosine receptor A1Function: G protein-coupled adenosine receptor activity
  4. Target

    Histamine H2 receptor

    go.drugbank.com/bio_entities/BE0000112
    TargetHumans

    G protein-coupled receptor for histamine, primarily mediating gastric acid secretion.

    Polypeptides: Histamine H2 receptorSynonyms: Gastric receptor I
  5. Target

    Histamine H4 receptor

    go.drugbank.com/bio_entities/BE0000146
    TargetHumans

    G protein-coupled receptor primarily expressed in immune cells such as mast cells, eosinophils, basophils, dendritic cells and neutrophils that plays a key role in immune and inflammatory responses (PubMed

    Polypeptides: Histamine H4 receptorSynonyms: G protein-coupled receptor 105
  6. Target

    Vasopressin V1a receptor

    go.drugbank.com/bio_entities/BE0000165
    TargetHumans

    Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

    Polypeptides: Vasopressin V1a receptorSynonyms: Antidiuretic hormone receptor 1a, Vascular/hepatic-type arginine vasopressin receptor
  7. Target

    Prostaglandin D2 receptor

    go.drugbank.com/bio_entities/BE0000296
    TargetHumans

    Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.

    Polypeptides: Prostaglandin D2 receptorSynonyms: PGD receptor, PGD2 receptor
  8. Target

    Adenosine receptor A3

    go.drugbank.com/bio_entities/BE0000354
    TargetHumans

    In lung mast cells, receptor activation contributes to the type I allergic response by facilitating mast cell degranulation and histamine release (By similarity). … G protein-coupled receptor (GPCR) for adenosine that plays significant roles in various physiological processes including immune regulation, cardioprotection and neuroprotection (PubMed:38627384, PubMed

    Polypeptides: Adenosine receptor A3Function: G protein-coupled adenosine receptor activity
  9. Target

    Histamine H1 receptor

    go.drugbank.com/bio_entities/BE0000442
    TargetHumans

    G protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). … Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules.

    Polypeptides: Histamine H1 receptorFunction: histamine receptor activity
  10. Target

    Ryanodine receptor 1

    go.drugbank.com/bio_entities/BE0000739
    TargetTransporterHumans

    Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:...

    Polypeptides: Ryanodine receptor 1Synonyms: Type 1 ryanodine receptor, Skeletal muscle ryanodine receptor