Search

Displaying results 5711 - 5720 of 10000 in total
  1. Drug

    Dupilumab

    go.drugbank.com/drugs/DB12159
    ApprovedInvestigational

    Dupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways. … [L7186] Dupilumab is commonly marketed as Dupixent, which is available as a formulation for subcutaneous injection. It was first approved by the FDA in 2017.

    Categories: Interleukin-4 Receptor alpha Antagonist, Interleukin 4 Receptor alpha AntagonistsProducts: DUPIXENT SOLUTION FOR INJECTION IN A PRE-FILLED SYRINGE 300 mg/2ml, DUPIXENT SOLUTION FOR INJECTION IN A PRE-FILLED SYRINGE 200 mg/1.14ml
  2. Indication

    Conditions where a reduction of gastric acid secretion is required

    go.drugbank.com/conditions/DBCOND0117234
    Drugs: Pantoprazole
    Synonyms: Conditions where a reduction of gastric acid secretion is required
  3. Drug

    Quetiapine

    go.drugbank.com/drugs/DB01224
    ApprovedInvestigational

    It is well-tolerated and a suitable option for some patients with high sensitivity to other drugs, such as [clozapine] and [olanzapine].[A2189] … [L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment.

    Mixtures: Quetialan 4 Tage Startpackung - Filmtabletten, Seroquel 4-Tage Startpackung FilmtablettenCategories: Dopamine D2 Receptor Antagonists, P-glycoprotein substrates
  4. Target

    Pleckstrin homology domain-containing family A member 4

    go.drugbank.com/bio_entities/BE0001278
    TargetHumans

    Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides

    Polypeptides: Pleckstrin homology domain-containing family A member 4Synonyms: PH domain-containing family A member 4
  5. Target

    Pleckstrin homology domain-containing family A member 1

    go.drugbank.com/bio_entities/BE0003262
    TargetHumans

    Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane

    Polypeptides: Pleckstrin homology domain-containing family A member 1Synonyms: PH domain-containing family A member 1
  6. Target

    Potassium voltage-gated channel subfamily A member 4

    go.drugbank.com/bio_entities/BE0004502
    TargetHumans

    Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368) … Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:19912772, PubMed:8495559).

    Polypeptides: Potassium voltage-gated channel subfamily A member 4
  7. Target

    A disintegrin and metalloproteinase with thrombospondin motifs 4

    go.drugbank.com/bio_entities/BE0004687
    EnzymeTargetHumans

    Could be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease … Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover (PubMed:10356395, PubMed:10827174). Also cleaves COMP (PubMed:39672391).

    Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 4
  8. Target

    Potassium voltage-gated channel subfamily A member 2

    go.drugbank.com/bio_entities/BE0004715
    TargetHumans

    In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed:8495559). … Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (By similarity)

    Polypeptides: Potassium voltage-gated channel subfamily A member 2
  9. Target

    Potassium voltage-gated channel subfamily A member 3

    go.drugbank.com/bio_entities/BE0004716
    TargetHumans

    Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with

    Polypeptides: Potassium voltage-gated channel subfamily A member 3
  10. Target

    Potassium voltage-gated channel subfamily A member 5

    go.drugbank.com/bio_entities/BE0004717
    TargetHumans

    May play a role in regulating the secretion of insulin in normal pancreatic islets … Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity

    Polypeptides: Potassium voltage-gated channel subfamily A member 5