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Tadalafil
go.drugbank.com/drugs/DB00820ApprovedInvestigational[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. … Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.
Mixtures: Finasteride and Tadalafil, OPSYNVI® (MACITENTAN/TADALAFILO) 10MG/40 MG TABLETAS RECUBIERTASCategories: tamsulosin and tadalafil, macitentan and tadalafilBenperidol
go.drugbank.com/drugs/DB12867ApprovedWithdrawnBenperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.
Products: GLIANIMON 10MG, GLIANIMON 2MG TABLETTENUndecylenic acid
go.drugbank.com/drugs/DB11117ApprovedUndecylenic acid was first isolated from the products of distillation of castor oil in 1877 via pyrolysis of ricinoleic acid, and has been polymerized for vinyl production [A32281]. … Undecylenate, or undecylenic acid, is an unsaturated fatty acid with a terminal double bond that is derived from castor oil. Undecylenic acid is also found naturally in the human sweat.
Mixtures: Foot and Body Powder, Fungi Nail Toe and Foot MSProducts: Fungi Nail Toe and Foot, Fungi Nail Toe and Foot PenTramadol
go.drugbank.com/drugs/DB00193ApprovedInvestigationalTramadol differs from other traditional opioid medications in that it doesn't just act as a μ-opioid agonist, but also affects monoamines by modulating the effects of neurotransmitters involved in the … These pathways are complementary and synergistic, improving tramadol's ability to modulate the perception of and response to pain.
Mixtures: DICLOFENACO SODICO /TRAMADOL HCL 25 MG/25MG., Trabest 37.5mg/325mg TabletsCategories: tramadol and celecoxib, tramadol and paracetamolInfliximab
go.drugbank.com/drugs/DB00065ApprovedInvestigationalThere are currently two biosilimars of infliximab available in the US market that demonstrate a high degree of similarity to the reference product, Remicade. … Infliximab was first approved by the FDA in 1998 under the market name Remicade as an intravenous injection.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: FLIXABI 100MG, REMSIMA 100MGFluorouracil
go.drugbank.com/drugs/DB00544ApprovedInvestigationalA pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Categories: Fluorouracil and prodrugs, Skin and Mucous Membrane AgentsProducts: BENDA 5 FU 50MG/ML 250MG, 5-FU INJECTION 250MG/5ML FLAKON, 10 ADETIntracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdb.ca/view/SMP0000320SignalingThe A2A receptor is also expressed in the brain, where it has important roles in the regulation of glutamate and dopamine release. … The A2A receptor is responsible for regulating myocardial blood flow by vasodilating the coronary arteries, which increases blood flow to the myocardium, but may lead to hypotension.
Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acidIntracellular Signalling Through Histamine H2 Receptor and Histamine
smpdb.ca/view/SMP0000335SignalingHistamine is an organic nitrogenous compound that is involved in local immune responses and it is a neurotransmitter for brain. … Histamine can mediate various actions by interacting with histamine receptors (H1, H2, H3 and H4).
Metabolism and Physiological Effects of Indoxyl glucoside (indican)
smpdb.ca/view/SMP0124742MetabolicIndoxyl glucoside (indican) is an indole compound that is formed through gut microbial metabolism from dietary tryptophan and a sulfation reaction in liver hepatic cells. … Indican is then excreted into the urine and from there into the diaper where, upon exposure to air, it is converted to indigo blue dye due to oxidation by atmospheric oxygen.
Metabolism and Phsyiological Effects of Asymmetric dimethylarginine (ADMA)
smpdb.ca/view/SMP0124747MetabolicAsymmetrical dimethylarginine (ADMA) is produced from L-arginine. L-arginine is obtained from protein-rich foods like red meat, poultry, dairy and eggs. It is absorbed in the intestine to the blood. … This elevates blood pressure, causes vasoconstriction, impairs endothelium-dependent relaxation, and increases endothelial cell adhesiveness.