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Displaying results 571 - 580 of 2828 in total
  1. Target

    Cytochrome b-c1 complex subunit 2, mitochondrial

    go.drugbank.com/bio_entities/BE0003855
    TargetHumans

    The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP … Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.

    Polypeptides: Cytochrome b-c1 complex subunit 2, mitochondrialSynonyms: Ubiquinol-cytochrome-c reductase complex core protein 2, Core protein II
  2. Target

    Cytochrome b-c1 complex subunit 6, mitochondrial

    go.drugbank.com/bio_entities/BE0003856
    TargetHumans

    Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. … (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport

    Polypeptides: Cytochrome b-c1 complex subunit 6, mitochondrialSynonyms: Complex III subunit 6, Complex III subunit VIII
  3. Target

    Inner membrane complex sub-compartment protein 3

    go.drugbank.com/bio_entities/BE0009269
    TargetPlasmodium falciparum (isolate 3D7)

    Polypeptides: Inner membrane complex sub-compartment protein 3
  4. Drug

    NADH

    go.drugbank.com/drugs/DB00157
    ApprovedNutraceutical

    NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved i...

  5. Drug

    Nigericin

    go.drugbank.com/drugs/DB14056
    Experimental

    A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed)

    Categories: Membrane Transport Modulators
  6. Drug

    Letermovir

    go.drugbank.com/drugs/DB12070
    ApprovedInvestigational

    Letermovir recieved approval from the FDA on November 8th, 2017 for use in prophylaxis of cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell transplant patients. … [L1021] It is the first of a new class of CMV anti-infectives called DNA terminase complex inhibitors.[A31290] Letermovir has recieved both priority and orphan drug status from the FDA.

    Categories: DNA Terminase Complex Inhibitors, Cytomegalovirus DNA Terminase Complex Inhibitor
  7. Drug

    Lumefantrine co-artemether

    go.drugbank.com/drugs/DB13085
    ApprovedInvestigationalWithdrawn

    Artemether, an artemisinin derivative, has several proposed mechanisms of action, including interference with plasmodial transport proteins, interference with mitochondrial electron transport, and the

  8. Drug

    Norgestimate

    go.drugbank.com/drugs/DB00957
    ApprovedInvestigational

    Norgestimate was first described in the literature in 1977. It was developed by Ortho Pharmaceutical Corporation as part of an effort to develop new hormonal contraceptives with reduced adverse effects. It is commonly formulated with eth...

    Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital System
  9. Drug

    Ferric maltol

    go.drugbank.com/drugs/DB15598
    ApprovedInvestigational

    Ferric maltol is an iron(III) atom complexed with 3 maltol molecules to increase the bioavailability compared to iron(II), without depositing it in the duodenum as insoluble ferric hydroxide and phosphate

  10. Drug

    Dorzolamide

    go.drugbank.com/drugs/DB00869
    ApprovedInvestigational

    Dorzolamide is a non-bacteriostatic sulfonamide derivative and topical carbonic anhydrase (CA) inhibitor that treats elevated intraocular pressure (IOP) associated with open-angle glaucoma and ocular hypertension. It works by blocking an...

    Mixtures: DORZOLAMID AL COMP ATR, DORZOLAMID AL COMP ATRCategories: Genito Urinary System and Sex Hormones