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3-oxo-5-alpha-steroid 4-dehydrogenase 1
go.drugbank.com/bio_entities/BE0000539TargetEnzymeHumansCatalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed
Polypeptides: 3-oxo-5-alpha-steroid 4-dehydrogenase 1Function: 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activityATP-binding cassette sub-family C member 4
go.drugbank.com/bio_entities/BE0001188TransporterTargetHumansATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells (PubMed:11856762, PubMed:12523936, PubMed:15364914, PubMed:38886124, PubMed:40138312). Transport...
Polypeptides: ATP-binding cassette sub-family C member 4Synonyms: Multidrug resistance-associated protein 44-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase
go.drugbank.com/bio_entities/BE0002977TargetClostridium aminobutyricumCatalyzes the reversible conversion of 4-hydroxybutyryl-CoA to crotonyl-CoA. … The mechanism of the reaction seems to go through three steps: (1) the FAD-dependent oxidation of 4-hydroxybutyryl-CoA to 4-hydroxycrotonyl-CoA; (2) the hydroxyl group is substituted by a hydride derived
Polypeptides: 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomeraseSynonyms: 4-BUDH4-hydroxy-3-methylbut-2-enyl diphosphate reductase
go.drugbank.com/bio_entities/BE0004045TargetEscherichia coli (strain K12)Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).
Polypeptides: 4-hydroxy-3-methylbut-2-enyl diphosphate reductaseSynonyms: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductaseNuclear receptor subfamily 4 group A member 3
go.drugbank.com/bio_entities/BE0008998TargetHumansTranscriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3'...
Polypeptides: Nuclear receptor subfamily 4 group A member 3Mitogen-activated protein kinase kinase kinase kinase 4
go.drugbank.com/bio_entities/BE0009473TargetHumansSerine/threonine kinase that plays a role in the response to environmental stress and cytokines such as TNF. Appears to act upstream of the JUN N-terminal pathway (PubMed:9890973). Activator of the Hippo signaling pathway which plays a p...
Polypeptides: Mitogen-activated protein kinase kinase kinase kinase 4Synonyms: MEKKK 4, MEK kinase kinase 4Dual specificity mitogen-activated protein kinase kinase 4
go.drugbank.com/bio_entities/BE0010122TargetHumansDual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2...
Polypeptides: Dual specificity mitogen-activated protein kinase kinase 4Synonyms: MEK 4, MAPKK 4Leukocyte immunoglobulin-like receptor subfamily A member 4
go.drugbank.com/bio_entities/BE0013620TargetHumansFunctions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic ...
Polypeptides: Leukocyte immunoglobulin-like receptor subfamily A member 4De Novo Triacylglycerol Biosynthesis TG(14:1(9Z)/20:4(5Z,8Z,11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))
smpdb.ca/view/SMP0020999MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
De Novo Triacylglycerol Biosynthesis TG(14:1(9Z)/18:4(6Z,9Z,12Z,15Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))
smpdb.ca/view/SMP0021099MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...