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Displaying results 5871 - 5880 of 10000 in total
  1. Pathway

    Acylcarnitine 2-Hydroxydecanoylcarnitine

    smpdb.ca/view/SMP0123852
    Metabolic

    2-Hydroxydecanoylcarnitine is an acylcarnitine. … Once in the matrix, 2-hydroxydecanoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form 2-hydroxydecanoyl-CoA and L-carnitine

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Carnitine O-palmitoyltransferase 2, mitochondrial
  2. Pathway

    Acylcarnitine 2-Dodecenoylcarnitine

    smpdb.ca/view/SMP0124007
    Metabolic

    2-Dodecenoylcarnitine is an acylcarnitine. … Once in the matrix, 2-dodecenoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form 2-dodecenoyl-CoA and L-carnitine. 2-Dodecenoyl-CoA

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Carnitine O-palmitoyltransferase 2, mitochondrial
  3. Pathway

    Acylcarnitine 2-Decenoylcarnitine

    smpdb.ca/view/SMP0123864
    Metabolic

    2-Decenoylcarnitine is an acylcarnitine. … Once in the matrix, 2-decenoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form 2-decenoyl-CoA and L-carnitine. 2-Decenoyl-CoA

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Carnitine O-palmitoyltransferase 2, mitochondrial
  4. Pathway

    Acylcarnitine 2-hydroxyicosanoylcarnitine

    smpdb.ca/view/SMP0124360
    Metabolic

    2-hydroxyicosanoylcarnitine is an acylcarnitine. … Once in the matrix, 2-hydroxyicosanoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form 2-hydroxyicosanoyl-CoA and L-carnitine

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Carnitine O-palmitoyltransferase 2, mitochondrial
  5. Drug

    Trabectedin

    go.drugbank.com/drugs/DB05109
    ApprovedInvestigational

    On October 23, 2015, the FDA approved trabectedin, (as Yondelis), for the treatment of specific soft tissue sarcomas. … Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery.

    Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic IndexProducts: YONDELIS 1 MG IV KONSANTRE INFUZYONLUK COZELTI ICIN TOZ, Yolisar 1 mg I.V. İnfüzyonluk Çözelti Hazırlamada Kullanılacak Konsantre İçin Toz, 1 ADET
  6. Target

    Transitional endoplasmic reticulum ATPase

    go.drugbank.com/bio_entities/BE0004572
    TargetHumans

    Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to...

    Synonyms: 15S Mg(2+)-ATPase p97 subunit
  7. Drug

    alpha-Tocopherol succinate

    go.drugbank.com/drugs/DB14001
    ApprovedNutraceuticalVet approved

    , males = 6 mg (9 IU) females = 6 mg (9 IU) in ages 1-3 years, males = 7 mg (10.4 IU) females = 7 mg (10.4 IU) in ages 4-8 years, males = 11 mg (16.4 IU) females = 11 mg (16.4 IU) in ages 9-13 years, males … The recommended dietary allowances (RDAs) for vitamin E alpha-tocopherol are: males = 4 mg (6 IU) females = 4 mg (6 IU) in ages 0-6 months, males = 5 mg (7.5 IU) females = 5 mg (7.5 IU) in ages 7-12 months

    Mixtures: V & M Vitamin and Mineral Supplement, Formula Ma-vitamin E & Zinc TabCategories: Heterocyclic Compounds, 2-Ring, Vitamin E
  8. Drug

    Nicergoline

    go.drugbank.com/drugs/DB00699
    Approved

    An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease.

    Categories: Cytochrome P-450 Substrates, Adrenergic alpha-1 Receptor AntagonistsSynonyms: (8β)-10-methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyridinecarboxylate (ester), 10-methoxy-1,6-dimethylergoline-8β-methanol 5-bromonicotinate
  9. Drug

    Thiotepa

    go.drugbank.com/drugs/DB04572
    ApprovedInvestigational

    It is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. … N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years.

    Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesSynonyms: N,N′,N′′-tri-1,2-ethanediyl-, Phosphorothioic triamide, N,N′,N′′-tri-1,2-ethanediyl-
  10. Drug

    Valbenazine

    go.drugbank.com/drugs/DB11915
    ApprovedInvestigational

    The reduction in chorea severity was observed as early as 2 weeks after starting treatment with an initial dose of 40 mg.[L47910] … [A261165] However, challenges in using [tetrabenazine] as a treatment of tardive dyskinesia included frequent dosing and safety and tolerability concerns.

    Categories: Heterocyclic Compounds, 2-Ring, Vesicular Monoamine Transporter 2 InhibitorProducts: REMLEAS HARD CAPSULES 40 MG, REMLEAS™ hard capsules 40mg