Search

Displaying results 581 - 590 of 661 in total
  1. Drug

    Budesonide

    go.drugbank.com/drugs/DB01222
    ApprovedInvestigational

    Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis. Budesonide was granted FDA approval o...

  2. Target

    Cyclin-dependent kinase 8

    go.drugbank.com/bio_entities/BE0002224
    TargetHumans

    Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. … Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression (PubMed:10993082).

    Synonyms: Mediator complex subunit CDK8
  3. Target

    Proteasome subunit alpha type-4

    go.drugbank.com/bio_entities/BE0003913
    TargetHumans

    Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)

    Synonyms: Multicatalytic endopeptidase complex subunit C9
  4. Target

    Atypical kinase COQ8A, mitochondrial

    go.drugbank.com/bio_entities/BE0009381
    TargetHumans

    Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:21296186, PubMed:25498144, PubMed:25540914, PubMed:27499294, PubM...

    Synonyms: Chaperone activity of bc1 complex-like
  5. Target

    Protein Rev

    go.drugbank.com/bio_entities/BE0010935
    TargetHuman immunodeficiency virus type 1 group M subtype B (isolate HXB2)

    Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex. … Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.

    Synonyms: Regulator of expression of viral proteins
  6. Target

    T-cell surface protein tactile

    go.drugbank.com/bio_entities/BE0012999
    TargetHumans

    May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK ce...

    Synonyms: T cell-activated increased late expression protein
  7. Drug

    Irofulven

    go.drugbank.com/drugs/DB05786
    Investigational

    Phase III clinical trials involving the drug have been underway since early 2001 at sites in the U.S. and Europe.

  8. Target

    Proteasome subunit beta type-6

    go.drugbank.com/bio_entities/BE0003919
    TargetHumans

    Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).

    Synonyms: Multicatalytic endopeptidase complex delta chain
  9. Drug

    Tofisopam

    go.drugbank.com/drugs/DB08811
    Investigational

    Although Tofisopam is not approved for sale in North America, it is approved for use in various countries worldwide, including parts of Europe.

  10. Target

    DNA polymerase epsilon subunit 3

    go.drugbank.com/bio_entities/BE0003617
    TargetHumans

    Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:14759371) … Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity).

    Synonyms: Chromatin accessibility complex 17 kDa protein