Search

Displaying results 51 - 60 of 446 in total
  1. Target

    Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

    go.drugbank.com/bio_entities/BE0005530
    TargetHumans

    Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). … In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049).

    Polypeptides: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENSynonyms: Phosphatase and tensin homolog
  2. Target

    High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

    go.drugbank.com/bio_entities/BE0003717
    TargetHumans

    Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299) … May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167).

    Polypeptides: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
  3. Target

    Acid ceramidase

    go.drugbank.com/bio_entities/BE0010906
    TargetHumans

    Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:12764132, PubMed:12815059). … Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (PubMed:10610716, PubMed:11451951, PubMed:15655246, PubMed:26898341, PubMed:36752535, PubMed

    Polypeptides: Acid ceramidaseSynonyms: Acid CDase
  4. Target

    Iduronic acid

    go.drugbank.com/bio_entities/BE0004822
    TargetHumans

  5. Target

    Uric acid

    go.drugbank.com/bio_entities/BE0004823
    TargetHumans

  6. Target

    Hyaluronic acid

    go.drugbank.com/bio_entities/BE0009857
    TargetHumans and other mammals

  7. Target

    Fatty acid

    go.drugbank.com/bio_entities/BE0009632
    Target

  8. Target

    Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

    go.drugbank.com/bio_entities/BE0018277
    TargetHumans

    Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). … Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity)

    Polypeptides: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1Synonyms: Leucine-rich repeat and immunoglobulin domain-containing protein 1
  9. Target

    Bile acid-CoA:amino acid N-acyltransferase

    go.drugbank.com/bio_entities/BE0002303
    TargetEnzymeHumans

    In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs (PubMed:12810727) … Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine (PubMed:12239217, PubMed:12810727, PubMed:2037576, PubMed:8034703).

    Polypeptides: Bile acid-CoA:amino acid N-acyltransferaseSynonyms: Bile acid-CoA thioesterase
  10. Target

    Fatty acid synthase

    go.drugbank.com/bio_entities/BE0000959
    TargetEnzymeHumans

    Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. … This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain

    Polypeptides: Fatty acid synthaseSynonyms: Type I fatty acid synthase