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Tamoxifen
go.drugbank.com/drugs/DB00675ApprovedInvestigational[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments. … Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.
Categories: UGT2B7 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexInternational brands: Nolvadex-DEplerenone
go.drugbank.com/drugs/DB00700ApprovedInvestigationalThe resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. … Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative
Products: EPLERENON AL 25MG FTA, EPLERENON AL 50MG FTATiotropium
go.drugbank.com/drugs/DB01409ApprovedInvestigationalTiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma. … [A180163] Tiotropium was granted FDA approval on 30 January 2004.[L7084]
Products: BROMURO DE TIOTROPIO 18 µG CÁPSULA, TIOSYNT BROMURO DE TIOTROPIO 18 MCG /POLVO PARA INHALACIONPhenytoin
go.drugbank.com/drugs/DB00252ApprovedInvestigationalVet approvedPhenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants. … [A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market.[A189219]
Categories: Inducers of Drug Clearance, Metabolic Side Effects of Drugs and SubstancesProducts: Epilan-D 100 mg - Tabletten, Epilan-D 50 mg/ml - AmpullenCefaclor
go.drugbank.com/drugs/DB00833ApprovedInvestigationalSemisynthetic, broad-spectrum antibiotic derivative of cephalexin.
Synonyms: 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acidProducts: Nu-cefaclor, Nu-cefaclor Capsules 250mgMesalazine
go.drugbank.com/drugs/DB00244ApprovedInvestigationalAlthough demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent … of mesalazine within microgranules [A174019].
Products: MELAZ 500 MG TABLETA DE LIBERACION RETARDADA, PENTASA®1 G GRANULOS DE LIBERACION PROLONGADANorfloxacin
go.drugbank.com/drugs/DB01059ApprovedInvestigationalA synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase.
Categories: Metabolic Side Effects of Drugs and SubstancesProducts: NORMED 400 - U, NORFLOXACIN AL 400MGCyclobenzaprine
go.drugbank.com/drugs/DB00924ApprovedInvestigational[A184982] It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond. … [A185039,A184982] Since its approval, it has remained relatively popular as an adjunctive, short-term treatment for acute skeletal muscle spasms secondary to musculoskeletal injury.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeSynonyms: (3-Dibenzo[a,d]cyclohepten-5-ylidene-propyl)-dimethyl-amine, N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-Δ5,γ-propylamineParecoxib
go.drugbank.com/drugs/DB08439ApprovedInvestigationalA letter of non-approval for parecoxib was issued by the FDA in 2005. … Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union.
Products: PARECOXB parecoxib (as sodium) 40mg powder for solution for injectionAzithromycin
go.drugbank.com/drugs/DB00207ApprovedInvestigationalAzithromycin [9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin] is a part of the _azalide_ subclass of macrolides, and contains a 15-membered ring, with a methyl-substituted nitrogen instead of a carbonyl … group at the 9a position on the aglycone ring, which allows for the prevention of its metabolism.
Products: Azithromycin Dr. Friedrich Eberth 500 mg Pulver für ein Konzentrat zur Herstellung einer Infusionslösung, Ag-azithromycin