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A disintegrin and metalloproteinase with thrombospondin motifs 5
go.drugbank.com/bio_entities/BE0003730TargetHumansMetalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chon...
Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 5Synonyms: ADAMTS-5, ADAM-TS 5Actin-related protein 2/3 complex subunit 5
go.drugbank.com/bio_entities/BE0004255TargetHumansComponent of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in th...
Polypeptides: Actin-related protein 2/3 complex subunit 5Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
go.drugbank.com/bio_entities/BE0009517TargetHumansPreferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281).
Polypeptides: Phosphatidylinositol 5-phosphate 4-kinase type-2 betaSynonyms: 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta, PI(5)P 4-kinase type II betaPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma
go.drugbank.com/bio_entities/BE0009518TargetHumansPhosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity.
Polypeptides: Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaSynonyms: PI(5)P 4-kinase type II gamma, Phosphatidylinositol 5-phosphate 4-kinase type II gammacAMP-specific 3',5'-cyclic phosphodiesterase 4 (PDE4)
go.drugbank.com/bio_entities/BE0009963TargetHumansHydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes
Polypeptides: 3',5'-cyclic-AMP phosphodiesterase 4A, 3',5'-cyclic-AMP phosphodiesterase 4BFunction: 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-AMP phosphodiesterase activityTuroctocog alfa
go.drugbank.com/drugs/DB09109ApprovedTuroctocog alfa is a recombinant factor VIII (rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the N-terminus and 11 amino acids from the C-terminus of the naturally … During secretion, some rFVIII molecules are cleaved at the C-terminal of the heavy chain (HC) at amino acid 720, and a monoclonal antibody binding C-terminal to this position is used in the purification
Products: NOVOEIGHT® 1500 UI POLVO ESTERIL PARA RECONSTITUIR A SOLUCIÓN INYECTABLE, NOVOEİGHT 250 IU ENJEKSİYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN TOZ VE ÇÖZÜCÜ, 1 ADETInterleukin-1 receptor type 1
go.drugbank.com/bio_entities/BE0000565TargetHumansAfter binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other … Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850)
Polypeptides: Interleukin-1 receptor type 1Synonyms: IL-1R-1, IL-1RT-1Aminosalicylic acid
go.drugbank.com/drugs/DB00233ApprovedInvestigationalAn antitubercular agent often administered in association with isoniazid. The sodium salt of the drug is better tolerated than the free acid.
Synonyms: 4-amino-2-hydroxybenzoic acid, 4-aminosalicylateCategories: 4-aminosalicylic acidPolistes fuscatus venom protein
go.drugbank.com/drugs/DB10959ApprovedPolistes fuscatus venom protein is an extract of Polistes fuscatus venom. Polistes fuscatus venom protein is used in allergenic testing.
Products: Wasp Venom Protein Multidose 13.0 Ml (1300 Mcg)Caspase-1
go.drugbank.com/bio_entities/BE0000444TargetHumansThiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin
Polypeptides: Caspase-1Synonyms: CASP-1, IL-1 beta-converting enzyme