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Displaying results 6121 - 6130 of 10000 in total
  1. Target

    Pappalysin-1

    go.drugbank.com/bio_entities/BE0009031
    TargetHumans

    Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. … Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF

    Polypeptides: Pappalysin-1
  2. Target

    Exportin-1

    go.drugbank.com/bio_entities/BE0009694
    TargetHumans

    Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase ...

    Polypeptides: Exportin-1Synonyms: Chromosome region maintenance 1 protein homolog
  3. Target

    Prohibitin 1

    go.drugbank.com/bio_entities/BE0009786
    TargetHumans

    Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcrip...

    Polypeptides: Prohibitin 1
  4. Target

    Syndecan-1

    go.drugbank.com/bio_entities/BE0010357
    TargetHumans

    Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660...

    Polypeptides: Syndecan-1
  5. Target

    Thrombospondin-1

    go.drugbank.com/bio_entities/BE0010410
    TargetHumans

    Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions (PubMed:15014436, PubMed:18285447, PubMed:2430973, PubMed:6489349). Multifunctional, involved in inflammation, angiogenesis, wound healing, reactive oxygen ...

    Polypeptides: Thrombospondin-1
  6. Target

    Prominin-1

    go.drugbank.com/bio_entities/BE0010464
    TargetHumans

    May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epi...

    Polypeptides: Prominin-1Synonyms: Prominin-like protein 1
  7. Target

    Stabilin-1

    go.drugbank.com/bio_entities/BE0010944
    TargetHumans

    Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, ...

    Polypeptides: Stabilin-1Synonyms: FEEL-1, MS-1 antigen
  8. Target

    Interleukin-1

    go.drugbank.com/bio_entities/BE0010992
    TargetHumans

    Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). … After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex (PubMed:17507369, PubMed:2950091).

    Polypeptides: Interleukin-1 alpha, Interleukin-1 betaSynonyms: IL-1 alpha, IL-1 beta
  9. Target

    Calmodulin-1

    go.drugbank.com/bio_entities/BE0012563
    TargetHumans

    Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:23893133, PubMed:2696975...

    Polypeptides: Calmodulin-1
  10. Target

    Cholinephosphotransferase 1

    go.drugbank.com/bio_entities/BE0017642
    TargetHumans

    Catalyzes the final step of de novo phosphatidylcholine (PC) synthesis, i.e. the transfer of choline phosphate from CDP-choline to the free hydroxyl of a diacylglycerol (DAG), producing a PC. It thereby plays a central role in the format...

    Polypeptides: Cholinephosphotransferase 1Synonyms: Diacylglycerol cholinephosphotransferase 1