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Displaying results 611 - 620 of 1993 in total
  1. Target

    Discoidin domain receptor

    go.drugbank.com/bio_entities/BE0027487
    TargetHumans

    It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. … Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation

    Polypeptides: Discoidin domain-containing receptor 2, Epithelial discoidin domain-containing receptor 1Synonyms: Discoidin domain receptor 2, Discoidin receptor tyrosine kinase
  2. Target

    Interleukin-2 receptor

    go.drugbank.com/bio_entities/BE0027978
    TargetHumans

    Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. … Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.

    Polypeptides: Cytokine receptor common subunit gamma, Interleukin-2 receptor subunit alphaSynonyms: IL-2 receptor subunit gamma, IL-2 receptor subunit alpha
  3. Drug

    Polyethylene glycol 400

    go.drugbank.com/drugs/DB11077
    ApprovedInvestigational

    Polyethylene glycols (PEGs) are products made of condensed ethylene oxide and water that can contain various derivatives and have various functions. Because many PEG types are hydrophilic, they are favorably used as enhancers of penetrat...

    Mixtures: Red Eye Workplace, Red Eye Triple Action
  4. Drug

    Pyrvinium

    go.drugbank.com/drugs/DB06816
    ApprovedInvestigationalWithdrawn

    Pyrvinium is an anthelmintic effective for pinworms. Several forms of pyrvinium have been prepared with variable counter anions, such as halides, tosylate, triflate and pamoate. Pyrvinum's anti-cancer properties are currently under inves...

  5. Drug

    Iluzanebart

    go.drugbank.com/drugs/DB18275
    Investigational

    Synonyms: Immunoglobulin G1 [296-cysteine,301-glycine,306-cysteine], anti-(human triggering receptor expressed on myeloid cells 2) (human monoclonal VGL101 γ1-chain), disulfide with human monoclonal VGL101 κ-chain
  6. Target

    Cannabinoid receptor 1

    go.drugbank.com/bio_entities/BE0000061
    TargetHumans

    G protein-coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such

    Polypeptides: Cannabinoid receptor 1Function: cannabinoid receptor activity
  7. Target

    Cannabinoid receptor 2

    go.drugbank.com/bio_entities/BE0000095
    TargetHumans

    Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase.

    Polypeptides: Cannabinoid receptor 2Function: cannabinoid receptor activity
  8. Target

    Substance-P receptor

    go.drugbank.com/bio_entities/BE0000384
    TargetHumans

    Substance P binding to its receptor triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C. … The rank order of affinity of this receptor to tachykinins is: substance P > neurokinin A/substance K > neurokinin B/neuromedin-K (PubMed:1718267).

    Polypeptides: Substance-P receptorSynonyms: NK-1 receptor, Tachykinin receptor 1
  9. Target

    Dopamine receptor D4

    go.drugbank.com/bio_entities/BE0000389
    TargetHumans

    G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure (PubMed:16423344 … Dopamine receptors can be classified in two categories: (1) DRD4 (together with DRD2 and DRD3) is a D2-type receptor and is coupled to G(i)/G(o) G proteins, mediating inhibition of adenylate cyclase activity

    Polypeptides: Dopamine receptor D4Synonyms: Dopamine D4 receptor, D(2C) dopamine receptor
  10. Target

    Endothelin-1 receptor

    go.drugbank.com/bio_entities/BE0000521
    TargetHumans

    Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

    Polypeptides: Endothelin-1 receptorSynonyms: Endothelin receptor type A