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Displaying results 6191 - 6200 of 10000 in total
  1. Target

    Toll-like receptor 2

    go.drugbank.com/bio_entities/BE0001164
    TargetHumans

    M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression (PubMed:15809303). … Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205).

    Polypeptides: Toll-like receptor 2
  2. Target

    Probable 2-phosphosulfolactate phosphatase

    go.drugbank.com/bio_entities/BE0001437
    TargetClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)

    Polypeptides: Probable 2-phosphosulfolactate phosphataseFunction: 2-phosphosulfolactate phosphatase activity
  3. Target

    Uridine-cytidine kinase 2

    go.drugbank.com/bio_entities/BE0001480
    TargetHumans

    Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine … , 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702)

    Polypeptides: Uridine-cytidine kinase 2Synonyms: UCK 2, Cytidine monophosphokinase 2
  4. Target

    (S)-2-haloacid dehalogenase

    go.drugbank.com/bio_entities/BE0001613
    TargetXanthobacter autotrophicus

    Acts on acids of short chain lengths, C(2) to C(4), with inversion of configuration at C-2 (PubMed:1744048). … Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids (PubMed:1744048).

    Polypeptides: (S)-2-haloacid dehalogenaseSynonyms: L-2-haloacid dehalogenase, 2-haloalkanoic acid dehalogenase
  5. Target

    Beta-lactamase OXA-2

    go.drugbank.com/bio_entities/BE0001778
    TargetSalmonella typhimurium

    This is an oxacillin-hydrolyzing beta-lactamase.

    Polypeptides: Beta-lactamase OXA-2
  6. Target

    Tryptophan--tRNA ligase 2

    go.drugbank.com/bio_entities/BE0001830
    TargetDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)

    Catalyzes the formation of 5'adenyl-Trp and tRNA(Trp) but with 5-fold less activity than TrpRS.

    Polypeptides: Tryptophan--tRNA ligase 2Synonyms: TrpRS 2, Tryptophanyl-tRNA synthetase 2
  7. Target

    DNA topoisomerase 2-beta

    go.drugbank.com/bio_entities/BE0002425
    TargetHumans

    Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken st...

    Polypeptides: DNA topoisomerase 2-beta
  8. Target

    Probable butyrate kinase 2

    go.drugbank.com/bio_entities/BE0002643
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    Polypeptides: Probable butyrate kinase 2Synonyms: BK 2, Branched-chain carboxylic acid kinase 2
  9. Target

    Thioredoxin reductase 2, mitochondrial

    go.drugbank.com/bio_entities/BE0003388
    TargetEnzymeHumans

    Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (PubMed:24601690). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling

    Polypeptides: Thioredoxin reductase 2, mitochondrial
  10. Target

    Arylamine N-acetyltransferase 2

    go.drugbank.com/bio_entities/BE0003607
    EnzymeHumans

    Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates (PubMed:12222688, PubMed:7915226). Participates in the detoxification of a plethora of hydrazine and arylamine drugs, and is able to bioactivate sev...

    Polypeptides: Arylamine N-acetyltransferase 2Synonyms: NAT-2, Arylamide acetylase 2