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Displaying results 621 - 630 of 2828 in total
  1. Drug

    Arzoxifene

    go.drugbank.com/drugs/DB06249
    ApprovedWithdrawn

  2. Drug

    Roxadustat

    go.drugbank.com/drugs/DB04847
    ApprovedInvestigational

    Roxadustat is a first-in-class hypoxia-inducible factor prolyl hydroxylase inhibitor used to treat anemia associated with chronic kidney disease. It works by reducing the breakdown of the hypoxia-inducible factor (HIF), which is a transc...

  3. Drug

    Methyltestosterone

    go.drugbank.com/drugs/DB06710
    ApprovedInvestigational

    A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methylt...

    Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital System
  4. Drug

    Cocaine

    go.drugbank.com/drugs/DB00907
    ApprovedIllicitInvestigational

    An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nerv...

    Categories: Membrane Transport Modulators
  5. Target

    ATP synthase F(1) complex subunit delta, mitochondrial

    go.drugbank.com/bio_entities/BE0000484
    TargetEnzymeHumans

    by electron transport complexes of the respiratory chain (Probable) (PubMed:37244256). … ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256).

    Polypeptides: ATP synthase F(1) complex subunit delta, mitochondrial
  6. Target

    Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

    go.drugbank.com/bio_entities/BE0001298
    TargetAzotobacter vinelandii

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

    Polypeptides: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complexSynonyms: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
  7. Target

    ATP synthase F(1) complex subunit alpha, mitochondrial

    go.drugbank.com/bio_entities/BE0003840
    TargetHumans

    by electron transport complexes of the respiratory chain (Probable). … ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256).

    Polypeptides: ATP synthase F(1) complex subunit alpha, mitochondrial
  8. Target

    Actin-related protein 2/3 complex subunit 1B

    go.drugbank.com/bio_entities/BE0004249
    TargetHumans

    Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). … The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079).

    Polypeptides: Actin-related protein 2/3 complex subunit 1BSynonyms: Arp2/3 complex 41 kDa subunit
  9. Target

    Actin-related protein 2/3 complex subunit 3

    go.drugbank.com/bio_entities/BE0004253
    TargetHumans

    Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). … The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079).

    Polypeptides: Actin-related protein 2/3 complex subunit 3Synonyms: Arp2/3 complex 21 kDa subunit
  10. Target

    ATP synthase F(0) complex subunit g, mitochondrial

    go.drugbank.com/bio_entities/BE0009022
    TargetHumans

    by electron transport complexes of the respiratory chain (PubMed:37244256). … Part of the complex F(0) domain (PubMed:37244256)

    Polypeptides: ATP synthase F(0) complex subunit g, mitochondrialFunction: proton transmembrane transporter activity