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Displaying results 621 - 630 of 10000 in total
  1. Drug

    Sulindac

    go.drugbank.com/drugs/DB00605
    ApprovedInvestigational

    While its full mechanism of action is not fully understood, sulindac is thought to primarily mediate its action by inhibiting prostaglandin synthesis by inhibiting COX-1 and COX-2. … Sulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide compound by liver enzymes.

    Categories: Antiinflammatory and Antirheumatic Products, Non-Steroids, Acetic Acid Derivatives and Related SubstancesProducts: Nu-sulindac Tab 150mg, Nu-sulindac Tab 200mg
  2. Drug

    Granisetron

    go.drugbank.com/drugs/DB00889
    ApprovedInvestigational

    A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.

    Categories: Alimentary Tract and Metabolism, Antiemetics and AntinauseantsProducts: KEVATRIL 2MG, GRANISETRON BETA 2MG
  3. Drug

    Cefaclor

    go.drugbank.com/drugs/DB00833
    ApprovedInvestigational

    Semisynthetic, broad-spectrum antibiotic derivative of cephalexin.

    Products: Nu-cefaclor Capsules 250mg, Nu-cefaclor
  4. Drug

    Sodium bicarbonate

    go.drugbank.com/drugs/DB01390
    ApprovedInvestigational

    Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.

    Mixtures: MILACID® SACHET POR 10ML SABOR MENTA, Bicarbonate Concentrate No 4202 LiqCategories: Antacids and Adsorbents, Blood and Blood Forming Organs
  5. Drug

    Solenopsis invicta

    go.drugbank.com/drugs/DB10419
    Approved

    Solenopsis invicta allergenic extract is used in allergenic testing.

    Synonyms: red imported fire ant allergenic extractMixtures: Insects whole body, Fire Ant Mix, Insects whole body, Fire Ant Mix
  6. Drug

    Quinapril

    go.drugbank.com/drugs/DB00881
    ApprovedInvestigational

    Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure. … [A184844] Quinapril was granted FDA approval on 19 November 1991.[L8420] A combination tablet with [hydrochlorothiazide] was also approved on 28 December 1999.[L8423]

    Mixtures: QUINAPLUS AL 20MG/25MG, ACCUZIDE 20MG/25MG DIUPLUSCategories: ACE Inhibitors and Diuretics, quinapril and diuretics
  7. Drug

    Itraconazole

    go.drugbank.com/drugs/DB01167
    ApprovedInvestigational

    [L50051] Itraconazole was first approved in the US in 1992 [L50056] and is available orally. … First synthesized in the early 1980s, itraconazole is a broad-spectrum triazole antifungal agent used to treat a variety of infections.

    Categories: Triazole and tetrazole derivatives, Metabolic Side Effects of Drugs and SubstancesProducts: Itrafungol Oral Solution 10mg/ml, JAMP ITRACONAZOLE ORAL SOLUTION 10MG/ML
  8. Drug

    Folic acid

    go.drugbank.com/drugs/DB00158
    ApprovedInvestigationalNutraceuticalVet approved

    [L5744] In order to function within the body, folic acid must first be reduced by the enzyme dihydrofolate reductase (DHFR) into the cofactors dihydrofolate (DHF) and tetrahydrofolate (THF). … This important pathway, which is required for de novo synthesis of nucleic acids and amino acids, is disrupted by anti-metabolite therapies such as [DB00563] as they function as DHFR inhibitors to prevent

    Synonyms: N-pteroyl-L-glutamic acid, N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acidMixtures: Folic Acid 1mg With C 20mg, Iron 25mg With Vit B-cmplx, Vit C, Cu & Mo
  9. Drug

    Lansoprazole

    go.drugbank.com/drugs/DB00448
    ApprovedInvestigational

    [A177065] It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux disease (GERD) … along with other pathologies caused by excessive acid secretion.

    Mixtures: Lansoprazole, Amoxicillin, and Clarithromycin, Lansoprazole, Amoxicillin and ClarithromycinCategories: Alimentary Tract and Metabolism, lansoprazole, amoxicillin and levofloxacin
  10. Drug

    Afoxolaner

    go.drugbank.com/drugs/DB11369
    ExperimentalVet approved

    Mixtures: Nexgard Spectra 75mg/15mg Chewable Tablets for Dogs >15-30kg, Nexgard Spectra 9mg/2mg Chewable Tablets for Dogs 2-3.5kgProducts: NexGard 28mg chewable tablets for dog > 4-10kg, NexGard 68mg chewable tablets for dogs > 10-25kg