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C5a anaphylatoxin chemotactic receptor 1
go.drugbank.com/bio_entities/BE0010095TargetHumansReceptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, … The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events
Polypeptides: C5a anaphylatoxin chemotactic receptor 1Synonyms: C5a anaphylatoxin chemotactic receptorInterferon alpha/beta receptor (IFNAR)
go.drugbank.com/bio_entities/BE0010136TargetHumansTogether with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:2153461 … Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity)
Polypeptides: Interferon alpha/beta receptor 1, Interferon alpha/beta receptor 2Synonyms: IFN-alpha/beta receptor 1, IFN-alpha/beta receptor 2Interleukin-1 receptor-like 2
go.drugbank.com/bio_entities/BE0010198TargetHumansReceptor for interleukin-36 (IL36A, IL36B and IL36G). … After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways
Polypeptides: Interleukin-1 receptor-like 2Synonyms: IL-36 receptor, Interleukin-1 receptor-related protein 2Interleukin-7 receptor subunit alpha
go.drugbank.com/bio_entities/BE0010557TargetHumansReceptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP)
Polypeptides: Interleukin-7 receptor subunit alphaSynonyms: IL-7 receptor subunit alphaSphingosine 1-phosphate receptor 2
go.drugbank.com/bio_entities/BE0012208TargetHumansReceptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617, PubMed:25274307). … Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity).
Polypeptides: Sphingosine 1-phosphate receptor 2Synonyms: S1P receptor 2, S1P receptor Edg-5N-formyl peptide receptor 2
go.drugbank.com/bio_entities/BE0012843TargetHumansDifferential signaling is also defined by receptor oligomerization state. … Pattern recognition G protein-coupled receptor (GPCR) that recognizes peptides with N-terminal formyl methionine, which are derived from invading pathogens or host mitochondria as pathogen or damage-associated
Polypeptides: N-formyl peptide receptor 2Synonyms: LXA4 receptor, Lipoxin A4 receptorNon-venereal endemic syphilis
go.drugbank.com/conditions/DBCOND0025727Drugs: Procaine benzylpenicillinSynonyms: BejelVorinostat
go.drugbank.com/drugs/DB02546ApprovedInvestigationalA recent study suggested that vorinostat also possesses some activity against recurrent glioblastoma multiforme, resulting in a median overall survival of 5.7 months (compared to 4 - 4.4 months in earlier
Benzoic acid
go.drugbank.com/drugs/DB03793ApprovedInvestigationalRecent research shows that sodium benzoate may be beneficial as an add-on therapy (1 gram/day) in schizophrenia. Total Positive and Negative Syndrome Scale scores dropped by 21% compared to placebo.
Peroxisome proliferator-activated receptor alpha
go.drugbank.com/bio_entities/BE0000071TargetHumansReceptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids.
Polypeptides: Peroxisome proliferator-activated receptor alphaSynonyms: Nuclear receptor subfamily 1 group C member 1