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Displaying results 641 - 650 of 2256 in total
  1. Target

    Toll-like receptor 8

    go.drugbank.com/bio_entities/BE0003518
    TargetHumans

    Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876, PubMed:32433612).

    Polypeptides: Toll-like receptor 8
  2. Target

    Somatostatin receptor type 3

    go.drugbank.com/bio_entities/BE0003529
    TargetHumans

    Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase

    Polypeptides: Somatostatin receptor type 3Function: G protein-coupled receptor activity
  3. Target

    Nuclear receptor ROR-beta

    go.drugbank.com/bio_entities/BE0003554
    TargetHumans

    Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence.

    Polypeptides: Nuclear receptor ROR-betaSynonyms: Nuclear receptor RZR-beta, Retinoid-related orphan receptor-beta
  4. Target

    Oxysterols receptor LXR-alpha

    go.drugbank.com/bio_entities/BE0003781
    TargetHumans

    Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920, PubMed:37478846). … Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by

    Polypeptides: Oxysterols receptor LXR-alphaSynonyms: Liver X receptor alpha, Nuclear receptor subfamily 1 group H member 3
  5. Target

    Nuclear receptor ROR-alpha

    go.drugbank.com/bio_entities/BE0004545
    TargetHumans

    Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence.

    Polypeptides: Nuclear receptor ROR-alphaSynonyms: Nuclear receptor RZR-alpha, RAR-related orphan receptor A
  6. Target

    5-hydroxytryptamine receptor 5A

    go.drugbank.com/bio_entities/BE0004688
    TargetHumans

    Also functions as a receptor for ergot alkaloid derivatives and other psychoactive substances (PubMed:35835867). … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35610220, PubMed:35835867

    Polypeptides: 5-hydroxytryptamine receptor 5ASynonyms: Serotonin receptor 5A
  7. Target

    Parathyroid hormone 2 receptor

    go.drugbank.com/bio_entities/BE0004703
    TargetHumans

    This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. … PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity)

    Polypeptides: Parathyroid hormone 2 receptorSynonyms: PTH2 receptor
  8. Target

    5-hydroxytryptamine 2 receptor

    go.drugbank.com/bio_entities/BE0004881
    TargetHumans

    Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelanocortin neurons and the release … Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:29398112).

    Polypeptides: 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2BSynonyms: Serotonin receptor 2A, Serotonin receptor 2B
  9. Target

    5-hydroxytryptamine receptor 2C

    go.drugbank.com/bio_entities/BE0004882
    TargetRat

    Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of … G-protein coupled receptor for 5-hydroxytryptamine (serotonin).

    Polypeptides: 5-hydroxytryptamine receptor 2CSynonyms: Serotonin receptor 2C, 5-hydroxytryptamine receptor 1C
  10. Target

    5-hydroxytryptamine receptor 2

    go.drugbank.com/bio_entities/BE0004957
    TargetHumans

    Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelanocortin neurons and the release … Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:29398112).

    Polypeptides: 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2BSynonyms: Serotonin receptor 2A, Serotonin receptor 2B