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Displaying results 651 - 660 of 3387 in total
  1. Drug

    Magnesium chloride

    go.drugbank.com/drugs/DB09407
    ApprovedInvestigational

    Magnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water.

    Mixtures: Isolyte S pH 7.4, DIANEAL PD-1 with Dextrose
  2. Drug

    Vecabrutinib

    go.drugbank.com/drugs/DB16657
    Investigational

    Vecabrutinib is under investigation in clinical trial NCT03037645 (Safety, PK, PD, and Antitumor Activity of Vecabrutinib (SNS-062) in B Lymphoid Cancers).

  3. Drug

    Pepsin

    go.drugbank.com/drugs/DB13198
    ApprovedWithdrawn

    Interestingly, recent research has suggested that pepsin participates in the digestion of nucleic acids [L2391].

  4. Drug

    Clozapine

    go.drugbank.com/drugs/DB00363
    ApprovedInvestigational

    Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-g...

    Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  5. Drug

    Tegafur

    go.drugbank.com/drugs/DB09256
    ApprovedInvestigational

    Tegafur (INN, BAN, USAN) is a prodrug of [DB00544] (5-FU), an antineoplastic agent used as the treatment of various cancers such as advanced gastric and colorectal cancers.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates
  6. Drug

    Diethyltoluamide

    go.drugbank.com/drugs/DB11282
    Approved

    Diethyltoluamide (DEET) is the common active ingredient in many insect repellent products. It is widely used to repel biting pests such as mosquitoes and ticks. Every year, DEET formulations are used to protect populations from mosquito-...

    International brands: Autan
  7. Target

    Type-1 angiotensin II receptor

    go.drugbank.com/bio_entities/BE0000062
    TargetHumans

    Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:15611106, PubMed:1567413, PubMed:25913193, PubMed:26420482 … The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers

    Polypeptides: Type-1 angiotensin II receptorSynonyms: AT1 receptor, Angiotensin II type-1 receptor
  8. Target

    Peroxisome proliferator-activated receptor gamma

    go.drugbank.com/bio_entities/BE0000215
    TargetHumans

    Ligand-activated transcription factor that forms obligate heterodimers with the retinoic acid receptor and acts as a key regulator of biological processes, such as adipocyte differentiation, lipid metabolism … Ligand-binding results in a conformational change in the receptor, promoting dissociation of repressors and recruitment of coactivators, and subsequent activation of target gene expression (PubMed:16150867

    Polypeptides: Peroxisome proliferator-activated receptor gammaSynonyms: Nuclear receptor subfamily 1 group C member 3
  9. Target

    Interferon alpha/beta receptor 2

    go.drugbank.com/bio_entities/BE0000385
    TargetHumans

    Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:10556041, PubMed:21854986, PubMed:26424569

    Polypeptides: Interferon alpha/beta receptor 2Synonyms: IFN-alpha/beta receptor 2, Type I interferon receptor 2
  10. Target

    Glutamate receptor ionotropic, NMDA 2C

    go.drugbank.com/bio_entities/BE0000454
    TargetHumans

    Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26875626, PubMed:36309015). Particip...

    Polypeptides: Glutamate receptor ionotropic, NMDA 2CSynonyms: N-methyl D-aspartate receptor subtype 2C, Glutamate [NMDA] receptor subunit epsilon-3