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Displaying results 61 - 70 of 536 in total
  1. Target

    Probable fatty acid synthase Fas (Fatty acid synthetase)

    go.drugbank.com/bio_entities/BE0009744
    TargetMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

    Polypeptides: Probable fatty acid synthase Fas (Fatty acid synthetase)
  2. Target

    Prostatic acid phosphatase

    go.drugbank.com/bio_entities/BE0001102
    TargetHumans

    Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (PubMed:10506173, PubMed:15280042) … A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins

    Polypeptides: Prostatic acid phosphataseSynonyms: Acid phosphatase 3
  3. Target

    Bile acid receptor

    go.drugbank.com/bio_entities/BE0001777
    TargetHumans

    Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). … ), VLDLR and SDC1 (involved in the hepatic uptake of LDL and IDL remnants), and inhibiting expression of MTTP (involved in VLDL assembly (PubMed:12554753, PubMed:12660231, PubMed:15337761).

    Polypeptides: Bile acid receptorFunction: bile acid binding
  4. Target

    alpha1-acid glycoprotein

    go.drugbank.com/bio_entities/BE0004879
    TargetCarrierHumans

    Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction … Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction

    Polypeptides: Alpha-1-acid glycoprotein 1, Alpha-1-acid glycoprotein 2
  5. Target

    A disintegrin and metalloproteinase with thrombospondin motifs 5

    go.drugbank.com/bio_entities/BE0003730
    TargetHumans

    Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN (PubMed:16133547, … Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration.

    Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 5Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 11
  6. Target

    Basement membrane-specific heparan sulfate proteoglycan core protein

    go.drugbank.com/bio_entities/BE0001031
    TargetHumans

    Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. … It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury.

    Polypeptides: Basement membrane-specific heparan sulfate proteoglycan core protein
  7. Target

    Sensor cyclic diguanylate phosphodiesterase, GAF and GAF domain-containing

    go.drugbank.com/bio_entities/BE0004305
    TargetGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)

    Polypeptides: Sensor cyclic diguanylate phosphodiesterase, GAF and GAF domain-containing
  8. Target

    Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

    go.drugbank.com/bio_entities/BE0009519
    TargetHumans

    May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380)

    Polypeptides: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
  9. Target

    Signal transducer and activator of transcription 1-alpha/beta

    go.drugbank.com/bio_entities/BE0010099
    TargetHumans

    Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 … and STAT2.

    Polypeptides: Signal transducer and activator of transcription 1-alpha/beta
  10. Target

    Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

    go.drugbank.com/bio_entities/BE0003558
    TargetHumans

    Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148) … Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:10725373, PubMed:10906126, PubMed:11050148, PubMed:16330539).

    Polypeptides: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11ASynonyms: cAMP and cGMP phosphodiesterase 11A